Abstract
Objective: To investigate the rate of colorectal neoplasms (CRNs) in patients who have Enterococcus faecalis infective endocarditis (EFIE) with available colonoscopies and to assess whether this is associated with the identification of a focus the infection. Patients and Methods: Retrospective analysis of data from a prospective multicenter study involving 35 centers who are members of the Grupo de Apoyo para el Manejo de la Endocarditis en España [Support Group for the Management of Infective Endocarditis in Spain] cohort. A specific set of queries regarding information on colonoscopy and histopathology of colorectal diseases was sent to each participating center. Four-hundred sixty-seven patients with EFIE were included from January 1, 2008, to December 31, 2017, from whom data on colonoscopy performance and results were available in 411 patients. Results: One hundred forty-two (34.5%) patients had a colonoscopy close to the EFIE episode. The overall rate of colorectal diseases was 70.4% (100 of 142), whereas the prevalence of CRN (advanced adenomas and colorectal carcinoma) was 14.8% (21 of 142), with no significant differences between the group of EFIE of unknown focus and that with an identified focus. Conclusion: Our study adds to prior evidence suggesting a much higher rate of CRN among patients with EFIE than in the general population of the same age and sex. In addition, our findings suggest that this phenomenon might take place both in EFIE with an unknown and an identified source of infection.
| Original language | English |
|---|---|
| Pages (from-to) | 132-146 |
| Number of pages | 15 |
| Journal | Mayo Clinic Proceedings |
| Volume | 96 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1 Jan 2021 |
Keywords
- Aged
- Aged, 80 and over
- Colonoscopy
- Colorectal Neoplasms/epidemiology
- Endocarditis, Bacterial/complications
- Enterococcus faecalis
- Female
- Gram-Positive Bacterial Infections/complications
- Humans
- Male
- Middle Aged
- Prevalence
- Retrospective Studies
- Risk Factors
- DIAGNOSIS
- AMPICILLIN PLUS GENTAMICIN
- MANAGEMENT
- CANCER
- THERAPY
- INFECTIVE ENDOCARDITIS
- ASSOCIATION
- SPAIN
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Prevalence of colorectal neoplasms among patients with Enterococcus faecalis endocarditis in the GAMES cohort (2008-2017). / Pericàs, J.M.; Ambrosioni, J.; Muñoz, P.; de Alarcón, A.; Kestler, M.; Mari-Hualde, A.; Moreno, A.; Goenaga, M.Á.; Fariñas, M.C.; Rodríguez-Álvarez, R.; Ojeda-Burgos, G.; Gálvez-Acebal, J.; Hidalgo-Tenorio, C.; Noureddine, M.; Miró, J.M.; Sánchez, F.F.; Rosas, G.; Lima, J.D.L.T.; Blanco, R.; Boado, M.V.; Lázaro, M.C.; Crespo, A.; Goikoetxea, J.; Iruretagoyena, J.R.; Zuazabal, J.I.; López-Soria, L.; Montejo, M.; Nieto, J.; Rodrigo, D.; Rodríguez, R.; Vitoria, Y.; Voces, R.; López, M.V.G.; Georgieva, R.I.; Ojeda, G.; Bailón, I.R.; Morales, J.R.; Cuende, A.M.; Echeverría, T.; Fuerte, A.; Gaminde, E.; Goenaga, M.Á.; Idígoras, P.; Iribarren, J.A.; Yarza, A.I.; Urkola, X.K.; Reviejo, C.; Carrasco, R.; Climent, V.; Llamas, P.; Merino, E.; Plazas, J.; Reus, S.; Álvarez, N.; Bravo-Ferrer, J.M.; Castelo, L.; Cuenca, J.; Llinares, P.; Rey, E.M.; Mayo, M.R.; Sánchez, E.; Regueiro, D.S.; Martínez, F.J.; del Mar Alonso, M.; Castro, B.; Rosado, D.G.; del Carmen Durán, M.; Gómez, M.A.M.; Lacalzada, J.; Nassar, I.; Ciezar, A.P.; Iglesias, J.M.R.; Álvarez, V.A.; Costas, C.; Hera, J.D.L.; Suárez, J.F.; Fraile, L.I.; Arguero, V.L.; Menéndez, J.L.; Bajo, P.M.; Morales, C.; Torrico, A.M.; Palomo, C.; Martínez, B.P.; Esteban, Á.R.; García, R.R.; Asensio, M.T.; Almela, M.; Azqueta, M.; Brunet, M.; Bodro, M.; Cartañá, R.; Falces, C.; Fita, G.; Fuster, D.; García de la Mària, C.; García-Pares, D.; Hernández-Meneses, M.; Pérez, J.L.; Marco, F.; Nicolás, D.; Ninot, S.; Quintana, E.; Paré, C.; Pereda, D.; Pericás, J.M.; Pomar, J.L.; Ramírez, J.; Rovira, I.; Sandoval, E.; Sitges, M.; Soy, D.; Téllez, A.; Tolosana, J.M.; Vidal, B.; Vila, J.; Adán, I.; Bermejo, J.; Bouza, E.; Celemín, D.; Caballero, G.C.; Montero, A.D.; Mansilla, A.G.; Leoni, M.E.G.; Ramallo, V.G.; Hernández, M.K.; Hualde, A.M.; Marín, M.; Martínez-Sellés, M.; Rincón, C.; Rodríguez-Abella, H.; Rodríguez-Créixems, M.; Pinilla, B.; Pinto, Á.; Valerio, M.; Vázquez, P.; Moreno, E.V.; Antorrena, I.; Loeches, B.; Quirós, A.M.; Moreno, M.; Ramírez, U.; Bastón, V.R.; Romero, M.; Saldaña, A.; Balbín, J.A.; Castillo, C.A.; Arnaiz, A.; de las Revillas, F.A.; Belaustegui, M.C.; Fariñas, M.C.; Fariñas-Álvarez, C.; Izquierdo, R.G.; García, I.; Rico, C.G.; Gutiérrez-Cuadra, M.; Díez, J.G.; Pajarón, M.; Parra, J.A.; Teira, R.; Zarauza, J.; Calderón Parra, J.; Cobo, M.; Domínguez, F.; Fortaleza, A.; Pavía, P.G.; González, J.; Cruz, A.F.; Múñez, E.; Ramos, A.; Romero, I.S.; Centella, T.; Hermida, J.M.; Moya, J.L.; Martín-Dávila, P.; Navas, E.; Oliva, E.; Río, A.D.; Rodríguez-Roda Stuart, J.; Tenorio, C.H.; Delia, M.A.; Araji, O.; Barquero, J.M.; Jambrina, R.C.; de Cueto, M.; Acebal, J.G.; Méndez, I.; Morales, I.; López-Cortés, L.E.; García, E.; Haro, J.L.; Lepe, J.A.; López, F.; Luque, R.; Alonso, L.J.; Azcárate, P.; Azcona Gutiérrez, J.M.; Blanco, J.R.; Villegas, A.C.; García-Álvarez, L.; Oteo, J.A.; Sanz, M.; de Benito, N.; Gurguí, M.; Pacho, C.; Pericas, R.; Pons, G.; Álvarez, M.; Fernández, A.L.; Martínez, A.T.; Prieto, A.; Regueiro, B.; Tijeira, E.; Vega, M.; Blasco, A.C.; Mollar, J.C.; Gainzarain Arana, J.C.; Uriarte, O.G.; López, A.M.; Ortiz de Zárate, Z.; Urturi Matos, J.A.; Gloria, G.-D.; Antonio, S.-P.; Leal, J.M.A.; Vázquez, E.G.; Torres, A.H.; Blázquez, A.; Valenzuela, G.D.L.M.; Alonso, Á.; Aramburu, J.; Calvo, F.E.; Rodríguez, A.M.; Tarabini-Castellani, P.; Gálvez, E.H.; Bellido, C.M.; Pau, J.L.; Sepúlveda, M.A.; Sierra, P.T.; Iqbal-Mirza, S.Z.; Alcolea, E.C.; Yañez, I.K.; Martínez, J.N.; Ballesta, A.P.; Escobar, E.M.; Monje, A.P.; Cabrera, V.S.; García, D.V.; Asenjo, M.A.; Luna, C.C.; Morcillo, J.N.; Seco, M.C.P.; Gelabert, A.V.; Guallar, C.A.; Abad, N.F.; Mangas, P.G.; Adell, M.M.; Ruiz, M.P.P.; Porres, J.C.; Vidal, B.A.; Trigueros, N.C.; Del Amor Espín, M.J.; Giner Caro, J.A.; Sánchez, R.J.; Almazán, A.J.; Freire, A.O.; González, M.V.; Ramis, P.P.; Blanco, M.Á.R.; Ruiz de Gopegui Bordes, E.; Bonet, L.V.; Munera, M.C.B.; Garaizabal, E.E.; Martínez, A.T.; Segura Luque, J.C.; Badía, C.; Palop, L.B.; Xercavins, M.; Eloy Gómez Nebreda, S.I.; Herrera, I.H.; Gallego Héctor Marrero Santiago, I.M.; de Miguel Martínez, I.; Álamo, E.P.
In: Mayo Clinic Proceedings, Vol. 96, No. 1, 01.01.2021, p. 132-146.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Prevalence of colorectal neoplasms among patients with Enterococcus faecalis endocarditis in the GAMES cohort (2008-2017).
AU - Pericàs, J.M.
AU - Ambrosioni, J.
AU - Muñoz, P.
AU - de Alarcón, A.
AU - Kestler, M.
AU - Mari-Hualde, A.
AU - Moreno, A.
AU - Goenaga, M.Á.
AU - Fariñas, M.C.
AU - Rodríguez-Álvarez, R.
AU - Ojeda-Burgos, G.
AU - Gálvez-Acebal, J.
AU - Hidalgo-Tenorio, C.
AU - Noureddine, M.
AU - Miró, J.M.
AU - Sánchez, F.F.
AU - Rosas, G.
AU - Lima, J.D.L.T.
AU - Blanco, R.
AU - Boado, M.V.
AU - Lázaro, M.C.
AU - Crespo, A.
AU - Goikoetxea, J.
AU - Iruretagoyena, J.R.
AU - Zuazabal, J.I.
AU - López-Soria, L.
AU - Montejo, M.
AU - Nieto, J.
AU - Rodrigo, D.
AU - Rodríguez, R.
AU - Vitoria, Y.
AU - Voces, R.
AU - López, M.V.G.
AU - Georgieva, R.I.
AU - Ojeda, G.
AU - Bailón, I.R.
AU - Morales, J.R.
AU - Cuende, A.M.
AU - Echeverría, T.
AU - Fuerte, A.
AU - Gaminde, E.
AU - Goenaga, M.Á.
AU - Idígoras, P.
AU - Iribarren, J.A.
AU - Yarza, A.I.
AU - Urkola, X.K.
AU - Reviejo, C.
AU - Carrasco, R.
AU - Climent, V.
AU - Llamas, P.
AU - Merino, E.
AU - Plazas, J.
AU - Reus, S.
AU - Álvarez, N.
AU - Bravo-Ferrer, J.M.
AU - Castelo, L.
AU - Cuenca, J.
AU - Llinares, P.
AU - Rey, E.M.
AU - Mayo, M.R.
AU - Sánchez, E.
AU - Regueiro, D.S.
AU - Martínez, F.J.
AU - del Mar Alonso, M.
AU - Castro, B.
AU - Rosado, D.G.
AU - del Carmen Durán, M.
AU - Gómez, M.A.M.
AU - Lacalzada, J.
AU - Nassar, I.
AU - Ciezar, A.P.
AU - Iglesias, J.M.R.
AU - Álvarez, V.A.
AU - Costas, C.
AU - Hera, J.D.L.
AU - Suárez, J.F.
AU - Fraile, L.I.
AU - Arguero, V.L.
AU - Menéndez, J.L.
AU - Bajo, P.M.
AU - Morales, C.
AU - Torrico, A.M.
AU - Palomo, C.
AU - Martínez, B.P.
AU - Esteban, Á.R.
AU - García, R.R.
AU - Asensio, M.T.
AU - Almela, M.
AU - Azqueta, M.
AU - Brunet, M.
AU - Bodro, M.
AU - Cartañá, R.
AU - Falces, C.
AU - Fita, G.
AU - Fuster, D.
AU - García de la Mària, C.
AU - García-Pares, D.
AU - Hernández-Meneses, M.
AU - Pérez, J.L.
AU - Marco, F.
AU - Nicolás, D.
AU - Ninot, S.
AU - Quintana, E.
AU - Paré, C.
AU - Pereda, D.
AU - Pericás, J.M.
AU - Pomar, J.L.
AU - Ramírez, J.
AU - Rovira, I.
AU - Sandoval, E.
AU - Sitges, M.
AU - Soy, D.
AU - Téllez, A.
AU - Tolosana, J.M.
AU - Vidal, B.
AU - Vila, J.
AU - Adán, I.
AU - Bermejo, J.
AU - Bouza, E.
AU - Celemín, D.
AU - Caballero, G.C.
AU - Montero, A.D.
AU - Mansilla, A.G.
AU - Leoni, M.E.G.
AU - Ramallo, V.G.
AU - Hernández, M.K.
AU - Hualde, A.M.
AU - Marín, M.
AU - Martínez-Sellés, M.
AU - Rincón, C.
AU - Rodríguez-Abella, H.
AU - Rodríguez-Créixems, M.
AU - Pinilla, B.
AU - Pinto, Á.
AU - Valerio, M.
AU - Vázquez, P.
AU - Moreno, E.V.
AU - Antorrena, I.
AU - Loeches, B.
AU - Quirós, A.M.
AU - Moreno, M.
AU - Ramírez, U.
AU - Bastón, V.R.
AU - Romero, M.
AU - Saldaña, A.
AU - Balbín, J.A.
AU - Castillo, C.A.
AU - Arnaiz, A.
AU - de las Revillas, F.A.
AU - Belaustegui, M.C.
AU - Fariñas, M.C.
AU - Fariñas-Álvarez, C.
AU - Izquierdo, R.G.
AU - García, I.
AU - Rico, C.G.
AU - Gutiérrez-Cuadra, M.
AU - Díez, J.G.
AU - Pajarón, M.
AU - Parra, J.A.
AU - Teira, R.
AU - Zarauza, J.
AU - Calderón Parra, J.
AU - Cobo, M.
AU - Domínguez, F.
AU - Fortaleza, A.
AU - Pavía, P.G.
AU - González, J.
AU - Cruz, A.F.
AU - Múñez, E.
AU - Ramos, A.
AU - Romero, I.S.
AU - Centella, T.
AU - Hermida, J.M.
AU - Moya, J.L.
AU - Martín-Dávila, P.
AU - Navas, E.
AU - Oliva, E.
AU - Río, A.D.
AU - Rodríguez-Roda Stuart, J.
AU - Tenorio, C.H.
AU - Delia, M.A.
AU - Araji, O.
AU - Barquero, J.M.
AU - Jambrina, R.C.
AU - de Cueto, M.
AU - Acebal, J.G.
AU - Méndez, I.
AU - Morales, I.
AU - López-Cortés, L.E.
AU - García, E.
AU - Haro, J.L.
AU - Lepe, J.A.
AU - López, F.
AU - Luque, R.
AU - Alonso, L.J.
AU - Azcárate, P.
AU - Azcona Gutiérrez, J.M.
AU - Blanco, J.R.
AU - Villegas, A.C.
AU - García-Álvarez, L.
AU - Oteo, J.A.
AU - Sanz, M.
AU - de Benito, N.
AU - Gurguí, M.
AU - Pacho, C.
AU - Pericas, R.
AU - Pons, G.
AU - Álvarez, M.
AU - Fernández, A.L.
AU - Martínez, A.T.
AU - Prieto, A.
AU - Regueiro, B.
AU - Tijeira, E.
AU - Vega, M.
AU - Blasco, A.C.
AU - Mollar, J.C.
AU - Gainzarain Arana, J.C.
AU - Uriarte, O.G.
AU - López, A.M.
AU - Ortiz de Zárate, Z.
AU - Urturi Matos, J.A.
AU - Gloria, G.-D.
AU - Antonio, S.-P.
AU - Leal, J.M.A.
AU - Vázquez, E.G.
AU - Torres, A.H.
AU - Blázquez, A.
AU - Valenzuela, G.D.L.M.
AU - Alonso, Á.
AU - Aramburu, J.
AU - Calvo, F.E.
AU - Rodríguez, A.M.
AU - Tarabini-Castellani, P.
AU - Gálvez, E.H.
AU - Bellido, C.M.
AU - Pau, J.L.
AU - Sepúlveda, M.A.
AU - Sierra, P.T.
AU - Iqbal-Mirza, S.Z.
AU - Alcolea, E.C.
AU - Yañez, I.K.
AU - Martínez, J.N.
AU - Ballesta, A.P.
AU - Escobar, E.M.
AU - Monje, A.P.
AU - Cabrera, V.S.
AU - García, D.V.
AU - Asenjo, M.A.
AU - Luna, C.C.
AU - Morcillo, J.N.
AU - Seco, M.C.P.
AU - Gelabert, A.V.
AU - Guallar, C.A.
AU - Abad, N.F.
AU - Mangas, P.G.
AU - Adell, M.M.
AU - Ruiz, M.P.P.
AU - Porres, J.C.
AU - Vidal, B.A.
AU - Trigueros, N.C.
AU - Del Amor Espín, M.J.
AU - Giner Caro, J.A.
AU - Sánchez, R.J.
AU - Almazán, A.J.
AU - Freire, A.O.
AU - González, M.V.
AU - Ramis, P.P.
AU - Blanco, M.Á.R.
AU - Ruiz de Gopegui Bordes, E.
AU - Bonet, L.V.
AU - Munera, M.C.B.
AU - Garaizabal, E.E.
AU - Martínez, A.T.
AU - Segura Luque, J.C.
AU - Badía, C.
AU - Palop, L.B.
AU - Xercavins, M.
AU - Eloy Gómez Nebreda, S.I.
AU - Herrera, I.H.
AU - Gallego Héctor Marrero Santiago, I.M.
AU - de Miguel Martínez, I.
AU - Álamo, E.P.
N1 - Publisher Copyright: © 2020 Mayo Foundation for Medical Education and Research Copyright: Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2021/1/1
Y1 - 2021/1/1
N2 - Objective: To investigate the rate of colorectal neoplasms (CRNs) in patients who have Enterococcus faecalis infective endocarditis (EFIE) with available colonoscopies and to assess whether this is associated with the identification of a focus the infection. Patients and Methods: Retrospective analysis of data from a prospective multicenter study involving 35 centers who are members of the Grupo de Apoyo para el Manejo de la Endocarditis en España [Support Group for the Management of Infective Endocarditis in Spain] cohort. A specific set of queries regarding information on colonoscopy and histopathology of colorectal diseases was sent to each participating center. Four-hundred sixty-seven patients with EFIE were included from January 1, 2008, to December 31, 2017, from whom data on colonoscopy performance and results were available in 411 patients. Results: One hundred forty-two (34.5%) patients had a colonoscopy close to the EFIE episode. The overall rate of colorectal diseases was 70.4% (100 of 142), whereas the prevalence of CRN (advanced adenomas and colorectal carcinoma) was 14.8% (21 of 142), with no significant differences between the group of EFIE of unknown focus and that with an identified focus. Conclusion: Our study adds to prior evidence suggesting a much higher rate of CRN among patients with EFIE than in the general population of the same age and sex. In addition, our findings suggest that this phenomenon might take place both in EFIE with an unknown and an identified source of infection.
AB - Objective: To investigate the rate of colorectal neoplasms (CRNs) in patients who have Enterococcus faecalis infective endocarditis (EFIE) with available colonoscopies and to assess whether this is associated with the identification of a focus the infection. Patients and Methods: Retrospective analysis of data from a prospective multicenter study involving 35 centers who are members of the Grupo de Apoyo para el Manejo de la Endocarditis en España [Support Group for the Management of Infective Endocarditis in Spain] cohort. A specific set of queries regarding information on colonoscopy and histopathology of colorectal diseases was sent to each participating center. Four-hundred sixty-seven patients with EFIE were included from January 1, 2008, to December 31, 2017, from whom data on colonoscopy performance and results were available in 411 patients. Results: One hundred forty-two (34.5%) patients had a colonoscopy close to the EFIE episode. The overall rate of colorectal diseases was 70.4% (100 of 142), whereas the prevalence of CRN (advanced adenomas and colorectal carcinoma) was 14.8% (21 of 142), with no significant differences between the group of EFIE of unknown focus and that with an identified focus. Conclusion: Our study adds to prior evidence suggesting a much higher rate of CRN among patients with EFIE than in the general population of the same age and sex. In addition, our findings suggest that this phenomenon might take place both in EFIE with an unknown and an identified source of infection.
KW - Aged
KW - Aged, 80 and over
KW - Colonoscopy
KW - Colorectal Neoplasms/epidemiology
KW - Endocarditis, Bacterial/complications
KW - Enterococcus faecalis
KW - Female
KW - Gram-Positive Bacterial Infections/complications
KW - Humans
KW - Male
KW - Middle Aged
KW - Prevalence
KW - Retrospective Studies
KW - Risk Factors
KW - DIAGNOSIS
KW - AMPICILLIN PLUS GENTAMICIN
KW - MANAGEMENT
KW - CANCER
KW - THERAPY
KW - INFECTIVE ENDOCARDITIS
KW - ASSOCIATION
KW - SPAIN
UR - http://www.scopus.com/inward/record.url?scp=85097385639&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/5565d466-1ab8-3b6e-a8af-cabb6610c662/
U2 - 10.1016/j.mayocp.2020.06.056
DO - 10.1016/j.mayocp.2020.06.056
M3 - Article
C2 - 33413809
VL - 96
SP - 132
EP - 146
IS - 1
ER -