Pretreatment count of peripheral neutrophils, monocytes, and lymphocytes as independent prognostic factor in patients with head and neck cancer

Cristina Valero, Laura Pardo, Montserrat López, Jacinto García, Mercedes Camacho, Miquel Quer, Xavier León

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)

Abstract

© 2016 Wiley Periodicals, Inc. Background: The purpose of this study was to analyze the prognostic value of pretreatment count of peripheral neutrophils, lymphocytes, monocytes, and neutrophil-to-lymphocyte ratio (NLR) in patients with head and neck squamous cell carcinoma (HNSCC). Methods: Local, regional, and distant recurrence-free survival and disease-specific survival were analyzed according to the count of neutrophils, lymphocytes, monocytes, and NLR. Results: We observed a decrease in disease-specific survival as the quartile category of neutrophils, monocytes, and NLR increased. In the case of lymphocytes, patients in the lower quartile had lower disease-specific survival. Considering the disease-specific survival as the dependent variable, a recursive partitioning analysis classified the patients according to the neutrophil and monocyte counts. Conclusion: High pretreatment count of peripheral neutrophils and/or monocytes was independently related with worse prognosis in patients with HNSCC. Classification based on pretreatment neutrophil and monocyte counts enabled the identification of different prognostic profiles. © 2016 Wiley Periodicals, Inc. Head Neck 39: 219–226, 2017.
Original languageEnglish
Pages (from-to)219-226
JournalHead and Neck
Volume39
Issue number2
DOIs
Publication statusPublished - 1 Feb 2017

Keywords

  • head and neck squamous cell carcinoma
  • lymphocytes
  • monocytes
  • neutrophil-to-lymphocyte ratio
  • neutrophils

Fingerprint Dive into the research topics of 'Pretreatment count of peripheral neutrophils, monocytes, and lymphocytes as independent prognostic factor in patients with head and neck cancer'. Together they form a unique fingerprint.

Cite this