Presynaptic actions of piribedil on the cardiovascular system of the pithed rat

A. Moron, L. Cuffi, E. Vila, A. Badia

    Research output: Contribution to journalArticleResearchpeer-review

    3 Citations (Scopus)

    Abstract

    The influence of piribedil on cardiovascular sympathetic responses has been studied in the pithed rat. Piribedil (0.3–1 mg kg−1) inhibited the increases of diastolic blood pressure induced by spinal cord electrical stimulation at the level Th5‐L4. This effect was reversed by sulpiride (0.3 mg kg−1) but not by yohimbine (0.3 mg kg−1). The cardiovascular responses induced by noradrenaline were unaffected by piribedil (0.3–1 mg kg−1). However piribedil (0.3–1 mg kg−1) did not modify the heart rate increase induced by spinal cord electrical stimulation at the C7‐Th1 level. These results suggest that piribedil inhibits the vascular sympathetic transmission in the pithed rat via stimulation of presynaptic dopamine receptors. Copyright © 1986, Wiley Blackwell. All rights reserved
    Original languageEnglish
    Pages (from-to)221-223
    JournalJournal of Pharmacy and Pharmacology
    Volume38
    Issue number3
    DOIs
    Publication statusPublished - 1 Jan 1986

    Fingerprint Dive into the research topics of 'Presynaptic actions of piribedil on the cardiovascular system of the pithed rat'. Together they form a unique fingerprint.

    Cite this