TY - JOUR
T1 - Prepulse inhibition and latent inhibition deficits in Roman high-avoidance vs. Roman low-avoidance rats: Modeling schizophrenia-related features
AU - Esnal, Aitor
AU - Sánchez-González, Ana
AU - Río-Álamos, Cristóbal
AU - Oliveras, Ignasi
AU - Cañete, Toni
AU - Blázquez, Gloria
AU - Tobeña, Adolf
AU - Fernández-Teruel, Alberto
PY - 2016/9/1
Y1 - 2016/9/1
N2 - © 2016 Elsevier Inc. The aim of the present study was to obtain further evidence supporting the validity of a new genetically-based rat model for the study of schizophrenia-relevant symptoms. The Roman high- (RHA-I) and low-avoidance (RLA-I) inbred rats have been psychogenetically selected for their rapid versus extremely poor acquisition of the two-way avoidance task in the shuttle box and present two well-differentiated profiles regarding several traits related to anxiety, impulsivity and sensitivity to (dopaminergic) psychostimulants. In this study we have tested animals from both strains in two behavioral paradigms that are related to schizophrenia, i.e. prepulse inhibition (PPI) and latent inhibition (LI) of fear-potentiated startle (FPS). The results show that while RLA-I rats display good PPI and LI to the context, RHA-Is show an impairment of PPI and no sign of an LI effect, which goes in the direction of the results obtained in schizophrenic patients. Therefore, although further behavioral and psychopharmacological work needs to be done, the present findings and previous studies carried out in our laboratory and others allow us to propose the RHA-I rat strain as a putative genetic rat model of differential schizophrenia-related features.
AB - © 2016 Elsevier Inc. The aim of the present study was to obtain further evidence supporting the validity of a new genetically-based rat model for the study of schizophrenia-relevant symptoms. The Roman high- (RHA-I) and low-avoidance (RLA-I) inbred rats have been psychogenetically selected for their rapid versus extremely poor acquisition of the two-way avoidance task in the shuttle box and present two well-differentiated profiles regarding several traits related to anxiety, impulsivity and sensitivity to (dopaminergic) psychostimulants. In this study we have tested animals from both strains in two behavioral paradigms that are related to schizophrenia, i.e. prepulse inhibition (PPI) and latent inhibition (LI) of fear-potentiated startle (FPS). The results show that while RLA-I rats display good PPI and LI to the context, RHA-Is show an impairment of PPI and no sign of an LI effect, which goes in the direction of the results obtained in schizophrenic patients. Therefore, although further behavioral and psychopharmacological work needs to be done, the present findings and previous studies carried out in our laboratory and others allow us to propose the RHA-I rat strain as a putative genetic rat model of differential schizophrenia-related features.
KW - Fear-potentiated startle
KW - Latent inhibition to a context
KW - Latent inhibition to a cue
KW - Prepulse inhibition
KW - Roman high- and low-avoidance rats
KW - Schizophrenia-related symptoms
U2 - 10.1016/j.physbeh.2016.05.020
DO - 10.1016/j.physbeh.2016.05.020
M3 - Article
SN - 0031-9384
VL - 163
SP - 267
EP - 273
JO - Physiology and Behavior
JF - Physiology and Behavior
ER -