Racemic 2,2,2-trifluoro-1-(1-pyrenyl)ethanol 2, was prepared and the (R)- and (S)-enantiomers obtained by preparative chiral HPLC. The behavior of these compounds as chiral solvating agents is studied with mixtures of several enantiomeric aromatic alcohols and amines. The non-linear distribution of aromatic rings in the pyrene appears to enhance the enantiodiscrimination capacity. © 2002 Elsevier Science Ltd. All rights reserved.
|Publication status||Published - 1 Aug 2002|
Muñoz, A., & Virgili, A. (2002). Preparation and behavior of (R)- and (S)-2,2,2-trifluoro-1-(1-pyrenyl)ethanol as chiral solvating agents: Study of the diastereomeric association by Job's plots, intermolecular NOE and binding constants. Tetrahedron Asymmetry, 13(14), 1529-1534. https://doi.org/10.1016/S0957-4166(02)00370-1