Premorbid adjustment and clinical correlates of cognitive impairment in first-episode psychosis: The PEPsCog Study

Manuel J. Cuesta, Ana M. Sánchez-Torres, Bibiana Cabrera, Miquel Bioque, Jessica Merchán-Naranjo, Iluminada Corripio, Ana González-Pinto, Antonio Lobo, Igor Bombín, Elena de la Serna, Julio Sanjuan, Mara Parellada, Jerónimo Saiz-Ruiz, Miquel Bernardo, Gisela Mezquida, Rafael Penadés, Ana Calvo, Celso Arango, Anna Alonso-Solís, Eva M. GrasaSonia Ruiz de Azua, Sara Barbeito, Leticia Gutiérrez-Galve, Fe Barconesi, Eduardo J. Aguilar, Daniel Bergé, Romina Cortizo, Carla Torrent, Eduard Vieta, Immaculada Baeza, Josefina Castro-Fornieles, Fernando Contreras, àuria Albacete, Susana Al-Halabí, Julio Bobes, Arantzazu Zabala, Roberto Rodriguez-Jimenez, Judith Usall, Salvador Sarró, ángela Ibáñez, Lucía Moreno-Izco, Vicent Balanzá-Martínez

    Research output: Contribution to journalArticleResearchpeer-review

    54 Citations (Scopus)

    Abstract

    © 2015 Elsevier B.V. Background: The extent to which socio-demographic, clinical, and premorbid adjustment variables contribute to cognitive deficits in first-episode schizophrenia spectrum disorders remains to be ascertained. Aims: To examine the pattern and magnitude of cognitive impairment in first-episode psychosis patients, the profile of impairment across psychosis subtypes and the associations with premorbid adjustment. Methods: 226 first-episode psychosis patients and 225 healthy controls were assessed in the PEPsCog study, as part of the PEPs study. Results: Patients showed slight to moderate cognitive impairment, verbal memory being the domain most impaired compared to controls. Broad affective spectrum patients had better premorbid IQ and outperformed the schizophrenia and other psychosis groups in executive function, and had better global cognitive function than the schizophrenia group. Adolescent premorbid adjustment together with age, gender, parental socio-economic status, and mean daily antipsychotic doses were the factors that best explained patients' cognitive performance. General and adolescent premorbid adjustment, age and parental socio-economic status were the best predictors of cognitive performance in controls. Conclusions: Poorer premorbid adjustment together with socio-demographic factors and higher daily antipsychotic doses were related to a generalized cognitive impairment and to a lower premorbid intellectual reserve, suggesting that neurodevelopmental impairment was present before illness onset.
    Original languageEnglish
    Pages (from-to)65-73
    JournalSchizophrenia Research
    Volume164
    Issue number1-3
    DOIs
    Publication statusPublished - 1 Jan 2015

    Keywords

    • Cognition
    • First episode psychosis
    • Premorbid adjustment
    • Schizophrenia spectrum disorders

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