Preimplantation genetic diagnosis in patients with male meiotic abnormalities

B. Aran, A. Veiga, F. Vidal, M. Parriego, J. M. Vendrell, J. Santaló, J. Egozcue, P. N. Barri

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17 Citations (Scopus)

Abstract

Indications and candidates for preimplantation genetic diagnosis (PGD) have increased in recent years. This study evaluates whether IVF-intracytoplasmic sperm injection (ICSI) results could be improved by selecting embryos through PGD-AS (aneuploidy screening) in couples in whom the male partner presents meiotic abnormalities. Two hundred and fifty-six embryos were biopsied and 183 were suitable for analysis (73.2%). Ninety-two embryos showed normal chromosomal analysis (50.3% of the analysed embryos and 57.5% of the diagnosed embryos). Pregnancy, abortion and implantation rates were compared with 66 IVF-ICSI cycles performed in 44 patients with meiotic abnormalities without PGD (control group). No statistically significant differences in the pregnancy rate (52 versus 43.9%), implantation rate (32.1 versus 23.5%) and miscarriage rate (15.4 versus 10.3%) were observed between the groups. Although the embryos obtained from men with meiotic abnormalities showed a high frequency of chromosome abnormalities, no improvements in pregnancy and implantation rates were obtained after PGD-AS in the series analysed.
Original languageEnglish
Pages (from-to)470-476
JournalReproductive BioMedicine Online
Volume8
Issue number4
DOIs
Publication statusPublished - 1 Jan 2004

Keywords

  • ICSI
  • Male meiotic abnormalities
  • PDG-AS

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