Preemptive-TIPS Improves Outcome in High-Risk Variceal Bleeding: An Observational Study * for the International Variceal Bleeding Observational Study Group and Baveno Cooperation

Virginia Hernández-Gea, Bogdan Procopet, Álvaro Giráldez, Lucio Amitrano, Candid Villanueva, Dominique Thabut, Luis Ibañez-Samaniego, Gilberto Silva-Junior, Javier Martinez, Joan Genescà, Christophe Bureau, Jonel Trebicka, Elba Llop, Wim Laleman, Jose Maria Palazon, Jose Castellote, Susana Rodrigues, Lise L Gluud, Carlos Noronha Ferreira, Rafael BarceloNuria Cañete, Manuel Rodríguez, Arnulf Ferlitsch, Jose Luis Mundi, Henning Gronbaek, Manuel Hernández-Guerra, Romano Sassatelli, Alessandra Dell'era, Marco Senzolo, Juan G Abraldes, Manuel Romero-Gómez, Alexander Zipprich, Meritxell Casas, Helena Masnou, Massimo Primignani, Aleksander Krag, Frederik Nevens, Jose Luis Calleja, Christian Jansen, Marie Angèle Robic, Irene Conejo, Maria-Vega Catalina, Agustin Albillos, Marika Rudler, Edilmar Alvarado, Maria Anna Guardascione, Marcel Tantau, Jaime Bosch, Ferran Torres, Juan Carlos Garcia-Pagán, Petra Fischer, Horia Stefanescu, Andreea Pop, Stig B Laursen, Fanny Turon, Anna Baiges, Claudia Berbel, Eira Cerda, Luis Tellez, Giulia Allegretti, Guilherme Macedo, David Haldrup, Patricia Santos, Miguel Moura, Daniela Reis, Liliane Meireles, Patricia Sousa, Paula Alexandrino, Carmen Navascues, Salvador Augustin, Vincenzo La Mura, Rafael Bañares, Raquel Diaz, Marta López Gómez, Cristina Ripoll

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Patients admitted with acute variceal bleeding (AVB) and Child-Pugh C score (CP-C) or Child-Pugh B plus active bleeding at endoscopy (CP-B+AB) are at high risk for treatment failure, rebleeding, and mortality. A preemptive transjugular intrahepatic portosystemic shunt (p-TIPS) has been shown to improve survival in these patients, but its use in clinical practice has been challenged and not routinely incorporated. The present study aimed to further validate the role of preemptive TIPS in a large number of high-risk patients. This multicenter, international, observational study included 671 patients from 34 centers admitted for AVB and high risk of treatment failure. Patients were managed according to current guidelines, and use of drugs and endoscopic therapy (D+E) or p-TIPS was based on individual center policy. p-TIPS in the setting of AVB is associated with a lower mortality in CP-C patients compared with D+E (1 year mortality 22% vs. 47% in D+E group; P = 0.002). Mortality rate in CP-B+AB patients was low, and p-TIPS did not improve it. In CP-C and CP-B+AB patients, p-TIPS reduced treatment failure and rebleeding (1-year cumulative incidence function probability of remaining free of the composite endpoint: 92% vs. 74% in the D+E group; P = 0.017) and development of de novo or worsening of previous ascites without increasing rates of hepatic encephalopathy. Conclusion: p-TIPS must be the treatment of choice in CP-C patients with AVB. Because of the strong benefit in preventing further bleeding and ascites, p-TIPS could be a good treatment strategy for CP-B+AB patients. (Hepatology 2019;69:282-293). A cute variceal bleeding (AVB) remains the most severe and life-threatening complication of portal hypertension in patients with cirrho-sis. In recent decades, a better understanding of AVB pathophysiology has led to a significant improvement in its management and a reduction in mortality rates. However, despite applying the gold-standard therapy , 10% to 15% of patients with AVB experience
Original languageEnglish
JournalHepatology
Volume69
Issue number1
Publication statusPublished - 2019

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