Predictors of early arterial reocclusion after tissue plasminogen activator-induced recanalization in acute ischemic stroke

Marta Rubiera, José Alvarez-Sabín, Marc Ribo, Joan Montaner, Esteban Santamarina, Juan F. Arenillas, Rafael Huertas, Pilar Delgado, Francisco Purroy, Carlos A. Molina

Research output: Contribution to journalArticleResearchpeer-review

176 Citations (Scopus)


Background and Purpose - We aimed to determine clinical and hemodynamic predictors of early reocdusion (RO) in stroke patients treated with intravenous tissue plasminogen activator (tPA). Methods - We studied 142 consecutive stroke patients with a documented middle cerebral artery (MCA) occlusion treated with intravenous tPA. All patients underwent carotid ultrasound and transcranial Doppler (TCD) examination before tPA bolus. National Institutes of Health Stroke Scale (NIHSS) scores were performed at baseline and serially for <24 hours. TCD monitoring of MCA recanalization (RE) and RO was performed during the first 2 hours after tPA bolus and repeated when clinical deterioration occurred <24 hours after documented RE in absence of intracranial hemorrhage. Results - After 1 hour of tPA administration, RE occurred in 84 (61%) patients (53 partial, 31 complete). Of these, 21 (25%) patients worsened after an initial improvement and 17 (12%) of them showed RO on TCD. RO was identified at a mean time of 65±55 minutes after documented RE. RO was associated (P=0.034) with a lower degree of 24-hour NIHSS score improvement than sustained RE, and a higher modified Rankin scale score at 3 months (P=0.002). Age older than 75 years (P=0.012), previous antiplatelet treatment (P=0.048), baseline NIHSS score >16 points (P=0.009), higher leukocytes count (P=0.042), beginning of RE <60 minutes after tPA bolus (P=0.039), and ipsilateral severe carotid stenosis/occlusion (P=0.001) were significantly associated with RO. In a logistic regression model, NIHSS score >16 at baseline (odds ratio [OR], 7.1; 95% CI, 1.3 to 32) and severe ipsilateral carotid disease (OR, 13.3; 95% CI, 3.2 to 54) remained as independent predictors of RO. Conclusions - Stroke severity and ipsilateral severe carotid artery disease independently predict RO after tPA-induced MCA RE. © 2005 American Heart Association, Inc.
Original languageEnglish
Pages (from-to)1452-1456
Issue number7
Publication statusPublished - 1 Jul 2005


  • Stroke
  • Thrombolysis
  • Transcranial doppler
  • Ultrasonography


Dive into the research topics of 'Predictors of early arterial reocclusion after tissue plasminogen activator-induced recanalization in acute ischemic stroke'. Together they form a unique fingerprint.

Cite this