Predictors of candidaemia caused by non-albicans Candida species: Results of a population-based surveillance in Barcelona, Spain

D. Rodríguez, B. Almirante, M. Cuenca-Estrella, J. L. Rodríguez-Tudela, J. Mensa, J. Ayats, F. Sanchez, A. Pahissa

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42 Citations (Scopus)

Abstract

Although Candida albicans (CA) is the most common cause of Candida bloodstream infections (BSIs), recent studies have observed an increasing percentage of candidaemias caused by non-albicans Candida species (NAC). In the present study, we attempted to identify the predictors of candidaemia due to NAC compared to CA. We analyzed data from an active population-based surveillance in Barcelona (Spain) from January 2002 to December 2003. Factors associated with NAC fungaemia were determined by multivariate analysis. A total of 339 episodes of Candida BSI, in 336 patients (median age 63-years, interquartile range: 41-72 years), were included. CA was the most commonly isolated (52%), followed by Candida parapsilosis (23%), Candida tropicalis (10%), Candida glabrata (8.6%), Candida krusei (3.4%) and other NAC spp. (3%).Overall, 48% of cases were due to NAC spp. Multivariate logistic regression analysis identified factors associated with a risk of BSI due to NAC spp.: having received a haematologic transplant (OR 10.8; 95% CI 1.31-90.01; p 0.027), previous fluconazole exposure (OR 4.47; 95% CI 2.12-9.43; p<0.001) and neonatal age (OR 4.42; 95% CI 1.63-12.04; p0.004). Conversely, previous CA colonization (OR 0.33; 95% CI 0.19-0.57; p0.001) and previous antibiotic use (OR 0.42; 95% CI 0.21-0.85; p0.017) were associated with CA fungaemia compared to NAC. In conclusion, NAC candidaemia comprised 48% of cases in our series. Predictors of NAC include having received a haematologic transplant, neonatal age and previous fluconazole use. © 2010 The Authors. Journal Compilation © 2010 European Society of Clinical Microbiology and Infectious Diseases.
Original languageEnglish
Pages (from-to)1676-1682
JournalClinical Microbiology and Infection
Volume16
Issue number11
DOIs
Publication statusPublished - 1 Jan 2010

Keywords

  • Candida albicans
  • Candidaemia
  • Non-albicans candida spp.
  • Predictors
  • Prognosis

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