Predictive value of angiogenic factors and uterine artery Doppler for early- versus late-onset pre-eclampsia and intrauterine growth restriction

F. Crispi, E. Llurba, C. Domínguez, P. Martín-Gallán, L. Cabero, E. Gratacós

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177 Citations (Scopus)

Abstract

Objectives: To investigate potential differences in the prediction of early- vs. late-onset pre-eclampsia and/or intrauterine growth restriction (PE/IUGR) by second-trimester uterine artery Doppler examination, and measurement of maternal serum placental growth factor (PlGF) and soluble fms-like tyrosine kinase 1 (sFlt1). Methods: Uterine artery mean pulsatility index (PI) and maternal serum PlGF and sFlt1 levels were measured at 24 weeks of gestation in 76 healthy pregnant women and 38 cases of PE/IUGR, of which 19 were defined as early onset (< 32 weeks). Results: For a specificity of 95%, the sensitivities of uterine artery mean PI, PlGF and sFlt1 for early-onset PE/IUGR were 47.4%, 84.4% and 36.8%, respectively. When combining uterine artery Doppler with PlGF, the sensitivity for identifying early-onset PE/IUGR was 89.5% with a specificity of 95%. Conversely, the sensitivity for late-onset PE/IUGR was below 11% for all parameters analyzed. Conclusions: Angiogenic factors and uterine artery Doppler evaluation may be useful second-trimester screening tests for early-onset, but not late-onset, PE/IUGR. Copyright © 2007 ISUOG. Published by John Wiley & Sons, Ltd.
Original languageEnglish
Pages (from-to)303-309
JournalUltrasound in Obstetrics and Gynecology
Volume31
Issue number3
DOIs
Publication statusPublished - 1 Mar 2008

Keywords

  • Angiogenesis
  • Intrauterine growth restriction
  • Placental growth factor
  • Pre-eclampsia
  • Soluble fms-like tyrosine kinase 1
  • Uterine artery Doppler

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