Preclinical memory profile in Alzheimer patients with and without allele APOE-epsilon4

Armando Estévez-González, Carmen García-Sánchez, Anunciación Boltes, Pilar Otermín, Montserrat Baiget, Antonio Escartín, Elisabeth Del Rio, Alex Gironell, Jaime Kulisevsky

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)


To investigate the association between APOE-ε4 allele and memory phenotype in the preclinical stage of Alzheimer's disease (AD). We compared an extensive preclinical memory profile at the baseline evaluation of 2 AD genotype groups: APOE-ε4 allele carriers and patients with APOE-ε3 homozygosity. Baseline memory performance was carried out at least 2 years (interval of 27.7 ± 4 months) before AD diagnosis was established, and analysis included different modalities of working memory (visuoperceptive, visuospatial, digit span and processing speed), of declarative memory (recent, verbal learning, prospective and semantic) and of nondeclarative memory (procedural, incidental and priming). We found no significant differences: memory performance was similar in both genotype groups. The presence of the APOE-ε4 allele does not seem to be sufficient to cause a distinctive preclinical memory phenotype in AD patients. Copyright © 2004 S. Karger AG, Basel.
Original languageEnglish
Pages (from-to)199-205
JournalEuropean Neurology
Issue number4
Publication statusPublished - 6 Jul 2004


  • Alzheimer's disease
  • APOE allele
  • Dementia
  • Genotype
  • Memory phenotype
  • Risk factors


Dive into the research topics of 'Preclinical memory profile in Alzheimer patients with and without allele APOE-epsilon4'. Together they form a unique fingerprint.

Cite this