TY - JOUR
T1 - Pravastatin for Preventing and Treating Preeclampsia
T2 - A Systematic Review
AU - Esteve-Valverde, Enrique
AU - Ferrer-Oliveras, Raquel
AU - Gil-Aliberas, Natàlia
AU - Baraldès-Farré, Antònia
AU - Llurba, Elisa
AU - Alijotas-Reig, Jaume
N1 - Copyright © Elsevier B.V
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PY - 2018/1
Y1 - 2018/1
N2 - IMPORTANCE: We have performed a systematic search to summarize the role of statins for preventing and treating severe preeclampsia.OBJECTIVE: The aim of this study was to examine whether pravastatin is a useful and safe alternative for treating preeclampsia during pregnancy.EVIDENCE ACQUISITION: A systematic MEDLINE (PubMed) search was performed (1979 to June 2017), which was restricted to articles published in English, using the relevant key words of "statins," "pregnancy," "preeclampsia," "obstetrical antiphospholipid syndrome," and "teratogenicity."RESULTS: The initial search provided 296 articles. Finally, 146 articles were related to the use of statins during pregnancy, regarding their effect on the fetus and the treatment of preeclampsia. Ten studies were related to in vitro studies, 25 in animals, and 24 in humans (13 case report series and 11 cohort studies). We found 84 studies on reviews of such guidelines on cardiovascular disease (35 studies), use of statins in the antiphospholipid syndrome (25 studies), statin's specific use during pregnancy (13 studies), or preeclampsia treatment (11 studies).CONCLUSIONS: Although the studies are of poor quality, the rate of major congenital abnormalities in the newborn exposed to statins during pregnancy is no higher than the expected when compared with overall risk population. The review shows a potential beneficial role of statins in preventing and treating severe preeclampsia that needs to be evaluated through well-designed clinical trials.RELEVANCE: This update could influence positively the clinical practice, giving an alternative therapy for clinicians who treat preeclampsia, particularly in severe cases.
AB - IMPORTANCE: We have performed a systematic search to summarize the role of statins for preventing and treating severe preeclampsia.OBJECTIVE: The aim of this study was to examine whether pravastatin is a useful and safe alternative for treating preeclampsia during pregnancy.EVIDENCE ACQUISITION: A systematic MEDLINE (PubMed) search was performed (1979 to June 2017), which was restricted to articles published in English, using the relevant key words of "statins," "pregnancy," "preeclampsia," "obstetrical antiphospholipid syndrome," and "teratogenicity."RESULTS: The initial search provided 296 articles. Finally, 146 articles were related to the use of statins during pregnancy, regarding their effect on the fetus and the treatment of preeclampsia. Ten studies were related to in vitro studies, 25 in animals, and 24 in humans (13 case report series and 11 cohort studies). We found 84 studies on reviews of such guidelines on cardiovascular disease (35 studies), use of statins in the antiphospholipid syndrome (25 studies), statin's specific use during pregnancy (13 studies), or preeclampsia treatment (11 studies).CONCLUSIONS: Although the studies are of poor quality, the rate of major congenital abnormalities in the newborn exposed to statins during pregnancy is no higher than the expected when compared with overall risk population. The review shows a potential beneficial role of statins in preventing and treating severe preeclampsia that needs to be evaluated through well-designed clinical trials.RELEVANCE: This update could influence positively the clinical practice, giving an alternative therapy for clinicians who treat preeclampsia, particularly in severe cases.
KW - Animals
KW - Disease Models, Animal
KW - Female
KW - Humans
KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology
KW - Placenta/blood supply
KW - Placentation/drug effects
KW - Pravastatin/pharmacology
KW - Pre-Eclampsia/drug therapy
KW - Pregnancy
KW - Randomized Controlled Trials as Topic
KW - Severity of Illness Index
U2 - 10.1097/OGX.0000000000000522
DO - 10.1097/OGX.0000000000000522
M3 - Review article
C2 - 29368790
SN - 0029-7828
VL - 73
SP - 40
EP - 55
JO - Obstetrical and Gynecological Survey
JF - Obstetrical and Gynecological Survey
IS - 1
ER -
