(Chemical Equation Presented) Faster than believed: Transmetalation from aryl boronic acids and triaryl boroxines to diethylzinc takes place within minutes following a two-step, low-energy pathway (see picture), according to density functional calculations and reaction microcalorimetry measurements. The experimental conditions for a practical, atom-economical, and highly enantioselective catalytic arylation of a variety of aldehydes have been developed from these data. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.
- Asymmetric catalysis
- Density functional calculations
- Reaction mechanisms