Practical aspects of the simultaneous collection of COSY and TOCSY spectra

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© 2019 John Wiley & Sons, Ltd. The practical aspects of some NMR experiments designed for the simultaneous acquisition of 2D COSY and 2D TOCSY spectra are presented and discussed. Several techniques involving afterglow-based, coherence transfer pathway (CTP)-based, and NMR by Ordered Acquisition using 1 H-detection (NOAH)-based strategies for the collection of different free-induction signal decays (FIDs) within the same scan are evaluated and compared. These methods offer a faster recording of these spectra in small-molecule NMR when sensitivity is not a limiting factor, with a reduction in spectrometer time about 45–60% when compared with the conventional sequential acquisition of the parent experiments. It is also shown how the optimized design of an extended three-FID approach yields one COSY and two TOCSY spectra simultaneously by combining CTP and NOAH principles in the same experiment, affording substantial sensitivity enhancements per time unit.
Original languageEnglish
Pages (from-to)85-94
JournalMagnetic Resonance in Chemistry
Publication statusPublished - 1 Apr 2019


  • COSY
  • COTO
  • MFA
  • multiple FID acquisition
  • NMR
  • NOAH


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