Postoperative serum Vascular Endothelial Growth Factor is an independent prognostic factor of disease free survival and overall survival in patients with non metastatic colon cancer

M. Pascual; S. Alonso; S. Salvans; X. Mayol; S. Mojal; M. J. Gil; L. Grande; M. Pera

doi:10.1016/j.amjsurg.2017.06.037

Postoperative serum Vascular Endothelial Growth Factor is an independent prognostic factor of disease free survival and overall survival in patients with non metastatic colon cancer

M. Pascual, S. Alonso, S. Salvans, X. Mayol, S. Mojal, M. J. Gil, L. Grande, M. Pera

Department of Surgery

Research output: Contribution to journal › Article › Research › peer-review

3 Citations (Scopus)

Abstract

© 2017 Elsevier Inc. Background: Angiogenesis is essential for tumor growth and formation of metastasis. VEGF is the most potent agiogenic citokine. The aim was to investigate the predictive value of postoperative VEGF serum concentration in patients undergoing surgery for colon cancer. Methods: Consecutive patients with colon cancer undergoing surgery with curative intent were included. VEGF was measured in serum at 48 h and postoperative day 4. Cox proportional hazards model was used to estimate its contribution with prognosis. Results: A total of 94 patients were included. On multivariate analysis VEGF on postoperative day 4 (HR: 1.05; p = 0.011) was independent prognostic factor of decreased DFS and OS. Five-year DFS (57.7% vs. 85%; p = 0.001) and OS (93% vs. 72%; p = 0.005) were significantly lower in patients with postoperative serum VEGF greater than 370 pg/dl. Conclusion: Postoperative VEGF serum concentration was an independent predictor of recurrence. These results must be verified in a prospective independent testing cohort.

Original language	English
Pages (from-to)	255-259
Journal	American Journal of Surgery
Volume	216
Issue number	2
DOIs	https://doi.org/10.1016/j.amjsurg.2017.06.037
Publication status	Published - 1 Aug 2018

Keywords

Colon cancer
Prognostic factor
Surgery
Vascular Endothelial Growth Factor

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.amjsurg.2017.06.037

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Pascual, M., Alonso, S., Salvans, S., Mayol, X., Mojal, S., Gil, M. J., Grande, L., & Pera, M. (2018). Postoperative serum Vascular Endothelial Growth Factor is an independent prognostic factor of disease free survival and overall survival in patients with non metastatic colon cancer. American Journal of Surgery, 216(2), 255-259. https://doi.org/10.1016/j.amjsurg.2017.06.037

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title = "Postoperative serum Vascular Endothelial Growth Factor is an independent prognostic factor of disease free survival and overall survival in patients with non metastatic colon cancer",

abstract = "{\textcopyright} 2017 Elsevier Inc. Background: Angiogenesis is essential for tumor growth and formation of metastasis. VEGF is the most potent agiogenic citokine. The aim was to investigate the predictive value of postoperative VEGF serum concentration in patients undergoing surgery for colon cancer. Methods: Consecutive patients with colon cancer undergoing surgery with curative intent were included. VEGF was measured in serum at 48 h and postoperative day 4. Cox proportional hazards model was used to estimate its contribution with prognosis. Results: A total of 94 patients were included. On multivariate analysis VEGF on postoperative day 4 (HR: 1.05; p = 0.011) was independent prognostic factor of decreased DFS and OS. Five-year DFS (57.7% vs. 85%; p = 0.001) and OS (93% vs. 72%; p = 0.005) were significantly lower in patients with postoperative serum VEGF greater than 370 pg/dl. Conclusion: Postoperative VEGF serum concentration was an independent predictor of recurrence. These results must be verified in a prospective independent testing cohort.",

keywords = "Colon cancer, Prognostic factor, Surgery, Vascular Endothelial Growth Factor",

author = "M. Pascual and S. Alonso and S. Salvans and X. Mayol and S. Mojal and Gil, {M. J.} and L. Grande and M. Pera",

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doi = "10.1016/j.amjsurg.2017.06.037",

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Pascual, M, Alonso, S, Salvans, S, Mayol, X, Mojal, S, Gil, MJ, Grande, L & Pera, M 2018, 'Postoperative serum Vascular Endothelial Growth Factor is an independent prognostic factor of disease free survival and overall survival in patients with non metastatic colon cancer', American Journal of Surgery, vol. 216, no. 2, pp. 255-259. https://doi.org/10.1016/j.amjsurg.2017.06.037

Postoperative serum Vascular Endothelial Growth Factor is an independent prognostic factor of disease free survival and overall survival in patients with non metastatic colon cancer. / Pascual, M.; Alonso, S.; Salvans, S. et al.

In: American Journal of Surgery, Vol. 216, No. 2, 01.08.2018, p. 255-259.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Postoperative serum Vascular Endothelial Growth Factor is an independent prognostic factor of disease free survival and overall survival in patients with non metastatic colon cancer

AU - Pascual, M.

AU - Alonso, S.

AU - Salvans, S.

AU - Mayol, X.

AU - Mojal, S.

AU - Gil, M. J.

AU - Grande, L.

AU - Pera, M.

PY - 2018/8/1

Y1 - 2018/8/1

N2 - © 2017 Elsevier Inc. Background: Angiogenesis is essential for tumor growth and formation of metastasis. VEGF is the most potent agiogenic citokine. The aim was to investigate the predictive value of postoperative VEGF serum concentration in patients undergoing surgery for colon cancer. Methods: Consecutive patients with colon cancer undergoing surgery with curative intent were included. VEGF was measured in serum at 48 h and postoperative day 4. Cox proportional hazards model was used to estimate its contribution with prognosis. Results: A total of 94 patients were included. On multivariate analysis VEGF on postoperative day 4 (HR: 1.05; p = 0.011) was independent prognostic factor of decreased DFS and OS. Five-year DFS (57.7% vs. 85%; p = 0.001) and OS (93% vs. 72%; p = 0.005) were significantly lower in patients with postoperative serum VEGF greater than 370 pg/dl. Conclusion: Postoperative VEGF serum concentration was an independent predictor of recurrence. These results must be verified in a prospective independent testing cohort.

AB - © 2017 Elsevier Inc. Background: Angiogenesis is essential for tumor growth and formation of metastasis. VEGF is the most potent agiogenic citokine. The aim was to investigate the predictive value of postoperative VEGF serum concentration in patients undergoing surgery for colon cancer. Methods: Consecutive patients with colon cancer undergoing surgery with curative intent were included. VEGF was measured in serum at 48 h and postoperative day 4. Cox proportional hazards model was used to estimate its contribution with prognosis. Results: A total of 94 patients were included. On multivariate analysis VEGF on postoperative day 4 (HR: 1.05; p = 0.011) was independent prognostic factor of decreased DFS and OS. Five-year DFS (57.7% vs. 85%; p = 0.001) and OS (93% vs. 72%; p = 0.005) were significantly lower in patients with postoperative serum VEGF greater than 370 pg/dl. Conclusion: Postoperative VEGF serum concentration was an independent predictor of recurrence. These results must be verified in a prospective independent testing cohort.

KW - Colon cancer

KW - Prognostic factor

KW - Surgery

KW - Vascular Endothelial Growth Factor

U2 - 10.1016/j.amjsurg.2017.06.037

DO - 10.1016/j.amjsurg.2017.06.037

M3 - Article

SN - 0002-9610

VL - 216

SP - 255

EP - 259

JO - American Journal of Surgery

JF - American Journal of Surgery

IS - 2

ER -

Postoperative serum Vascular Endothelial Growth Factor is an independent prognostic factor of disease free survival and overall survival in patients with non metastatic colon cancer

Abstract

Keywords

UN SDGs

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