Post-weaning crowding induces corticoadrenal hyperreactivity in male mice

R. Ortiz, A. Armario, J. M. Castellanos, J. Balasch

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)


The effect of various population densities on corticoadrenal function was studied in prepuberal male mice. High population densities decreased body weight gain. Neither adrenal weight nor basal serum corticosterone were modified by crowding. However, corticoadrenal response to some acute stresses such as noise and forced swimming was higher in crowded mice. As corticoadrenal response to adrenocorticotropin remained unaffected, it appears that crowding induced pituitary-adrenal hyperreactivity. Neither the defecation rate nor exploratory activity were altered by crowding, suggesting a dissociation between pituitary-adrenal responsiveness and behavioral measures presumably related to emotional arousal. These discrepancies may possibly be due to the higher sensitivity of corticoadrenal function to environmental changes. Our results suggest that crowding would be suitable as a model for chronic continuous stress. © 1985.
Original languageEnglish
Pages (from-to)857-860
JournalPhysiology and Behavior
Publication statusPublished - 1 Jan 1985


  • Corticosterone
  • Crowding
  • Emotionality
  • Forced swimming
  • Noise
  • Pituitary-adrenal axis
  • Stress


Dive into the research topics of 'Post-weaning crowding induces corticoadrenal hyperreactivity in male mice'. Together they form a unique fingerprint.

Cite this