Post-surgical changes in brain metabolism detected by magnetic resonance spectroscopy in normal pressure hydrocephalus: Results of a pilot study

María Del Mar Matarín, Roser Pueyo, María Antonia Poca, Carles Falcón, María Mataró, Núria Bargalló, Juan Sahuquillo, Carme Junqué

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Abstract

Background: Adult normal pressure hydrocephalus (NPH) is one of the few potentially treatable causes of dementia. Some morphological and functional abnormalities attributed to hydrocephalus improve following treatment. Objectives: We focused on analysis of changes in cerebral metabolites using proton magnetic resonance spectroscopy (1H-MRS) after NPH treatment, and its clinical and cognitive correlation. Methods: 1H-MRS, neuropsychological and clinical status examinations were performed before and 6 months after shunting in 12 adults with idiopathic NPH. We obtained N-acetyl-aspartate (NAA), choline (Cho), myoinositol (MI) and creatine (Cr) values. Results: After surgery, NAA/Cr was significantly increased. Moreover, NAA/Cr values were related to cognitive deterioration. Conclusion: MRS could be a marker of neuronal dysfunction in NPH.
Original languageEnglish
Pages (from-to)760-763
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume78
DOIs
Publication statusPublished - 1 Jan 2007

Fingerprint Dive into the research topics of 'Post-surgical changes in brain metabolism detected by magnetic resonance spectroscopy in normal pressure hydrocephalus: Results of a pilot study'. Together they form a unique fingerprint.

Cite this