Post-neurosurgical and spontaneous gram-negative bacillary meningitis in adults

Jordi Mancebo, Pere Doming, Lluis Blanch, Pere Coll, Alvar Net, Joan Nolla

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In order to evaluate the clinical aspects of gram-negative bacillary meningitis (GNBM) we reviewed the charts of 20 adult patients with the discharge diagnosis of meningitis caused by gram-negative bacilli (bacteriologically proved) seen between 1973 and 1984. Nine patients had post-neurosurgical (post-NS) GNBM and 11 patients spontaneous (S) GNBM; the mean age of the former was 42 ± 16 years and of the latter 56±14 years (p>0.05). The overall mortality rate was 50% (33% in the post-NS group and 64% in the S group). The glucose levels in CSF were significantly lower in the patients who died. Patients treated with combined aminoglycoside therapy presented a lower mortality rate than those treated with intravenous aminoglycoside only (25% versus 70% We suggest that if aminoglycoside therapy is employed, these antibiotics must be administered both intravenously and directly into CNS. © 1986 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
Original languageEnglish
Pages (from-to)533-538
JournalScandinavian Journal of Infectious Diseases
Issue number6
Publication statusPublished - 1 Jan 1986


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