Polymorphisms of alcohol-metabolizing enzymes and the risk for alcoholism and alcoholic liver disease in Caucasian Spanish women

Alfons Lorenzo, Teresa Auguet, Francesc Vidal, Montserrat Broch, Montserrat Olona, Cristina Gutiérrez, Miguel López-Dupla, Joan Josep Sirvent, Joan Carles Quer, Mauro Santos, Cristóbal Richart

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Abstract

Background: The relationship of polymorphisms of the genes that encode for alcohol-metabolizing enzymes and individual vulnerability to alcoholism and alcoholic liver disease (ALD) in women is unclear. We determined the genotypes of ADH1B, ADH1C, CYP2E1 (Dra-I and Pst-I) and ALDH2 in a group of Caucasian Spanish women. Methods: We performed a cross-sectional case-control study. The study group was made of 220 women. Of these, 85 were alcoholic (27 without liver disease and 58 with alcoholic liver disease) and 135 were non-alcoholic (42 healthy controls and 93 with liver disease unrelated to alcohol). Genotyping of alcohol-metabolizing enzymes was performed using PCR-RFLP methods. Results: The distribution of the allelic variants (alleles 1 and 2) in the whole subjects analyzed was: ADH1B 91.6% and 8.4%; ADH1C 58.4% and 41.6%; CYP2E1 Dra-I 15% and 85%; CYP2E1 Pst-I 96.8% and 3.2%; and ALDH2 100% and 0%, respectively. Carriage of genotypes containing the ADH1B*2 mutant allele significantly protected against alcoholism [odds-ratio (OR) = 0.00; 95% confidence interval (95% CI): 0.00-0.94; p = 0.02] but was associated with an increased risk for alcoholic liver disease among alcohol-dependent women [OR = 0.43; 95% CI: 0.18-0.41; p = 0.004]. Analysis of the remaining loci showed no significant associations. Conclusions: In Caucasian Spanish women the ADH1B*2 allele modulates the risk for alcohol dependence and for alcoholic liver disease. Given the small number of alcoholic women analyzed here, these data need further validation in larger cohorts. © 2006 Elsevier Ireland Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)195-200
JournalDrug and Alcohol Dependence
Volume84
DOIs
Publication statusPublished - 15 Sep 2006

Keywords

  • Alcohol dehydrogenase
  • Alcoholic liver disease
  • Alcoholism
  • Aldehyde dehydrogenase
  • Cytochrome P4502E1
  • Women

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    Lorenzo, A., Auguet, T., Vidal, F., Broch, M., Olona, M., Gutiérrez, C., López-Dupla, M., Sirvent, J. J., Quer, J. C., Santos, M., & Richart, C. (2006). Polymorphisms of alcohol-metabolizing enzymes and the risk for alcoholism and alcoholic liver disease in Caucasian Spanish women. Drug and Alcohol Dependence, 84, 195-200. https://doi.org/10.1016/j.drugalcdep.2006.03.002