Polymorphism of RANTES chemokine gene promoter is not associated with long-term nonprogressive HIV-1 infection of more than 16 years

Francesc Vidal*, Joaquim Peraire, Pere Domingo, Montserrat Broch, Mireia Cairó, Enric Pedrol, Milagros Montero, Consuelo Viladés, Cristina Gutiérrez, Ma Antònia Sambeat, Àngels Fontanet, David Dalmau, Elisabeth Deig, Hernando Knobel, Joan Josep Sirvent, Cristóbal Richart

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Abstract

To examine whether polymorphisms of the RANTES chemokine gene promoter are associated with long-term nonprogressive HIV-1 infection in white Spanish subjects, we performed a cross-sectional genetic association case-control study. Two-hundred sixty-seven white Spaniards were studied: 58 were HIV-1-infected long-term nonprogressors (LTNPs) of more than 16 years, 109 were HIV-1-infected usual progressors (UPs), and 100 were control subjects. Three RANTES single nucleotide polymorphisms (SNPs) at positions -28C>G, - 109T>C, and -403G>A were assessed. The prevalence of the CCR5Δ 32 allele was also examined. Genotyping was performed using polymerase chain reaction and automatic sequencing analysis methods. Genotype and allele frequencies between the 3 groups were compared by the χ2 test and the Fisher exact test. The distribution of allelic variants of RANTES in controls, UPs, and LTNPs, respectively, was 3%, 2%, and 5% for -28G; 4%, 2%, and 2% for - 109C; and 18%, 18%, and 18% for -403A (P = not significant). The differences were still nonsignificant when we exclusively analyzed individuals not carrying the CCR5Δ32 allele. We conclude that LTNP of more than 16 years is not associated with SNPs in the RANTES gene promoter in white Spanish HIV-1-infected subjects.

Original languageAmerican English
Pages (from-to)17-22
Number of pages6
JournalJournal of Acquired Immune Deficiency Syndromes
Volume41
Issue number1
DOIs
Publication statusPublished - Jan 2006

Keywords

  • AIDS
  • CCR5
  • HIV-1 infection
  • Long-term nonprogressors
  • Polymorphism
  • RANTES

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