TY - JOUR
T1 - Polymorphism of RANTES chemokine gene promoter is not associated with long-term nonprogressive HIV-1 infection of more than 16 years
AU - Vidal, Francesc
AU - Peraire, Joaquim
AU - Domingo, Pere
AU - Broch, Montserrat
AU - Cairó, Mireia
AU - Pedrol, Enric
AU - Montero, Milagros
AU - Viladés, Consuelo
AU - Gutiérrez, Cristina
AU - Sambeat, Ma Antònia
AU - Fontanet, Àngels
AU - Dalmau, David
AU - Deig, Elisabeth
AU - Knobel, Hernando
AU - Sirvent, Joan Josep
AU - Richart, Cristóbal
PY - 2006/1/1
Y1 - 2006/1/1
N2 - To examine whether polymorphisms of the RANTES chemokine gene promoter are associated with long-term nonprogressive HIV-1 infection in white Spanish subjects, we performed a cross-sectional genetic association case-control study. Two-hundred sixty-seven white Spaniards were studied: 58 were HIV-1-infected long-term nonprogressors (LTNPs) of more than 16 years, 109 were HIV-1-infected usual progressors (UPs), and 100 were control subjects. Three RANTES single nucleotide polymorphisms (SNPs) at positions -28C>G, - 109T>C, and -403G>A were assessed. The prevalence of the CCR5Δ 32 allele was also examined. Genotyping was performed using polymerase chain reaction and automatic sequencing analysis methods. Genotype and allele frequencies between the 3 groups were compared by the χ2 test and the Fisher exact test. The distribution of allelic variants of RANTES in controls, UPs, and LTNPs, respectively, was 3%, 2%, and 5% for -28G; 4%, 2%, and 2% for - 109C; and 18%, 18%, and 18% for -403A (P = not significant). The differences were still nonsignificant when we exclusively analyzed individuals not carrying the CCR5Δ32 allele. We conclude that LTNP of more than 16 years is not associated with SNPs in the RANTES gene promoter in white Spanish HIV-1-infected subjects. Copyright © 2005 by Lippincott Williams & Wilkins.
AB - To examine whether polymorphisms of the RANTES chemokine gene promoter are associated with long-term nonprogressive HIV-1 infection in white Spanish subjects, we performed a cross-sectional genetic association case-control study. Two-hundred sixty-seven white Spaniards were studied: 58 were HIV-1-infected long-term nonprogressors (LTNPs) of more than 16 years, 109 were HIV-1-infected usual progressors (UPs), and 100 were control subjects. Three RANTES single nucleotide polymorphisms (SNPs) at positions -28C>G, - 109T>C, and -403G>A were assessed. The prevalence of the CCR5Δ 32 allele was also examined. Genotyping was performed using polymerase chain reaction and automatic sequencing analysis methods. Genotype and allele frequencies between the 3 groups were compared by the χ2 test and the Fisher exact test. The distribution of allelic variants of RANTES in controls, UPs, and LTNPs, respectively, was 3%, 2%, and 5% for -28G; 4%, 2%, and 2% for - 109C; and 18%, 18%, and 18% for -403A (P = not significant). The differences were still nonsignificant when we exclusively analyzed individuals not carrying the CCR5Δ32 allele. We conclude that LTNP of more than 16 years is not associated with SNPs in the RANTES gene promoter in white Spanish HIV-1-infected subjects. Copyright © 2005 by Lippincott Williams & Wilkins.
KW - AIDS
KW - CCR5
KW - HIV-1 infection
KW - Long-term nonprogressors
KW - Polymorphism
KW - RANTES
U2 - 10.1097/01.qai.0000188335.86466.ea
DO - 10.1097/01.qai.0000188335.86466.ea
M3 - Article
VL - 41
SP - 17
EP - 22
IS - 1
ER -