TY - GEN
T1 - POINT-OF-CARE MICROFLUIDIC PLATFORM FOR THE DETECTION OF KEY MOLECULES IN BLOOD RELATED TO DIFFERENT DISEASES
AU - Rebollo-Calderon, Beatriz
AU - Serrano, Elena Alberto
AU - Calvo-López, Antonio
AU - Puyol, Mar
AU - Alonso-Chamarro, Julian
N1 - Publisher Copyright:
© 2021 MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. All rights reserved.
PY - 2021
Y1 - 2021
N2 - A versatile and disposable cyclic olefin copolymer (COC)-based point-of-care (POC) microfluidic platform is hereby presented for the potentiometric determination in blood of NH4+ or other key nitrogenous biomolecules related to inherited metabolic diseases (IMD). Maximum selectivity has been achieved thanks to passive pretreatment stages. High versatility of the microfluidic platform has been demonstrated by the optimization and characterization of the analysis of two model analytes: ammonium (direct determination) and urea (indirect determination using urease). Very promising results have been obtained to progress towards a microanalyzer that could be used by the patient himself for at-home diseases monitoring.
AB - A versatile and disposable cyclic olefin copolymer (COC)-based point-of-care (POC) microfluidic platform is hereby presented for the potentiometric determination in blood of NH4+ or other key nitrogenous biomolecules related to inherited metabolic diseases (IMD). Maximum selectivity has been achieved thanks to passive pretreatment stages. High versatility of the microfluidic platform has been demonstrated by the optimization and characterization of the analysis of two model analytes: ammonium (direct determination) and urea (indirect determination using urease). Very promising results have been obtained to progress towards a microanalyzer that could be used by the patient himself for at-home diseases monitoring.
KW - ammonium ion
KW - enzyme
KW - microfluidics
KW - point-of-care
KW - potentiometric determination
UR - http://www.scopus.com/inward/record.url?scp=85136962196&partnerID=8YFLogxK
M3 - Other contribution
AN - SCOPUS:85136962196
T3 - MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences
ER -