Point-of-care microanalizer for potentiometric determination of ammonium in plasma

Beatriz Rebollo-Calderon*, Antonio Calvo-Lopez, Aida Ormazabal, Mar Puyol, Rafael Artuch, Julian Alonso-Chamarro

*Corresponding author for this work

Research output: Other contribution


A cyclic olefin copolymer (COC)-based continuous flow potentiometric point-of-care (POC) microanalyzer is hereby presented for the bedside determination of ammonium ion in plasma of patients affected by diseases causing hyperammonemia episodes, such as urea cycle disorders (UCDs). The microanalyzer integrates microfluidics, a potentiometric detection system with an ammonium ion selective electrode (ISE) and a Ag/AgCl reference electrode, and a gas diffusion membrane to enhance selectivity avoiding matrix interferences. Real samples have been analyzed obtaining highly promising results.

Original languageEnglish
Number of pages2
ISBN (Electronic)9781733419017
Publication statusPublished - 2020

Publication series

NameMicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences


  • Ammonium ion
  • Microfluidics
  • Point-of-care
  • Polymer technology
  • Potentiometric detection


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