Podocyturia: Why it may have added value in rare diseases

Maria Dolores Sanchez-Niño, Maria Vanessa Perez-Gomez, Lara Valiño-Rivas, Roser Torra, Alberto Ortiz

Research output: Contribution to journalArticleResearch

8 Citations (Scopus)


© The Author(s) 2018. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. Fabry disease is an inherited lysosomal disease in which defects in the GLA gene lead to a-galactosidase-A deficiency, and accumulation of glycosphingolipids, including lyso-Gb3, a podocyte stressor. Therapy is available as enzyme replacement therapy and, for some patients, the chaperone migalastat. A key decision is when to start therapy, given its costs and potential impact on some aspects of quality of life. The decision is especially difficult in otherwise asymptomatic patients. A delayed start of therapy may allow kidney injury to progress subclinically up to the development of irreversible lesions. Non-invasive tools to monitor subclinical kidney injury are needed. One such tool may be assessment of podocyturia. In this issue of CKJ, [Trimarchi H, Canzonieri R, Costales-Collaguazo C et al. Early decrease in the podocalyxin to synaptopodin ratio in urinary Fabry podocytes. Clin Kidney J 2019; doi.org/10.1093/ckj/ sfy053] report on podocyturia assessment in Fabry nephropathy. Specifically, they report that podocalyxin may be lost from detached urinary podocytes.
Original languageEnglish
Pages (from-to)49-52
Number of pages4
JournalCKJ: Clinical Kidney Journal
Issue number1
Publication statusPublished - 5 Oct 2018


  • Fabry
  • podocalyxin
  • podocyte
  • podocyturia
  • synaptopodin


Dive into the research topics of 'Podocyturia: Why it may have added value in rare diseases'. Together they form a unique fingerprint.

Cite this