Pneumonia as comorbidity in chronic obstructive pulmonary disease (COPD). Differences between acute exacerbation of COPD and pneumonia in patients with COPD

Ramon Boixeda, Sandra Bacca, Lorena Elias, Josep Anton Capdevila, Xavier Vila, Montserrat Mauri, Jordi Almirall

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Abstract

© 2013 SEPAR. Introduction: Pneumonia is considered an independent entity in chronic obstructive pulmonary disease (COPD), to be distinguished from an infectious exacerbation of COPD. The aim of this study was to analyze the clinical characteristics and progress of the exacerbation of COPD (ECOPD) compared to pneumonia in COPD (PCOPD) patients requiring hospitalization. Patients and methods: Prospective, longitudinal, observational cohort study including 124 COPD patients requiring hospital admission for lower respiratory tract infection. Patients were categorized according to presence of ECOPD (n. = 104) or PCOPD (n. = 20), depending on presence of consolidation on X-ray. Demographic, clinical, laboratory, microbiological and progress variables were collected. Results: Patients with ECOPD showed more severe respiratory disease according to the degree of obstruction (P<. .01) and need for oxygen therapy ( P<. .05). PCOPD patients showed increased presence of fever (P<. .05), lower blood pressure ( P<. .001), more laboratory abnormalities ( P<. .05; leukocytosis, elevated CRP, low serum albumin) and increased presence of crepitus ( P<. .01). Microbiological diagnosis was achieved in 30.8% of cases of ECOPD and 35% of PCOPD; sputum culture yielded the highest percentage of positive results, predominantly Pseudomonas aeruginosa. Regarding the progress of the episode, no differences were found in hospital stay, need for ICU or mechanical ventilation. Conclusions: Our data confirm clinical and analytical differences between ECOPD and PCOPD in patients who require hospital admission, while there were no differences in subsequent progress.
Original languageEnglish
Pages (from-to)514-520
JournalArchivos de Bronconeumologia
Volume50
Issue number12
DOIs
Publication statusPublished - 1 Dec 2014

Keywords

  • Acute exacerbation
  • Chronic obstructive pulmonary disease
  • Hospitalization
  • Pneumonia
  • Respiratory infection

Fingerprint Dive into the research topics of 'Pneumonia as comorbidity in chronic obstructive pulmonary disease (COPD). Differences between acute exacerbation of COPD and pneumonia in patients with COPD'. Together they form a unique fingerprint.

  • Cite this