Pluronic F127 micelles improve the stability and enhance the anticancer stem cell efficacy of citral in breast cancer

Marwa M. Abu-Serie; Fernanda Andrade; Patricia Cámara-Sánchez; Joaquin Seras-Franzoso; DIana Rafael; Zamira V. DÍaz-Riascos; Petra Gener; Ibane Abasolo; Simó Schwartz

doi:10.2217/nnm-2021-0013

Pluronic F127 micelles improve the stability and enhance the anticancer stem cell efficacy of citral in breast cancer

Marwa M. Abu-Serie^*, Fernanda Andrade, Patricia Cámara-Sánchez, Joaquin Seras-Franzoso, DIana Rafael, Zamira V. DÍaz-Riascos, Petra Gener, Ibane Abasolo, Simó Schwartz

^*Corresponding author for this work

Department of Genetics and Microbiology

Research output: Contribution to journal › Article › Research › peer-review

8 Citations (Scopus)

Abstract

Aim: Improving the stability and anti-cancer stem cell (CSC) activity of citral, a natural ALDH1A inhibitor. Materials & methods: Citral-loaded micelles (CLM) were obtained using Pluronic® F127 and its efficacy tested on the growth of four breast cancer cell lines. The impact of the CLM on the growth and functional hallmarks of breast CSCs were also evaluated using mammosphere and CSC reporter cell lines. Results: CLM improved the stability and growth inhibitory effects of citral. Importantly, CLM fully blocking the stemness features of CSCs (self-renewal, differentiation and migration) and in combination with paclitaxel CLM sensitized breast cancer cells to the chemotherapy. Conclusion: Targeting CSCs with CLM could improve the treatment of advanced breast cancer in combination with the standard chemotherapy.

Original language	English
Pages (from-to)	1471-1485
Number of pages	15
Journal	Nanomedicine
Volume	16
Issue number	17
DOIs	https://doi.org/10.2217/nnm-2021-0013
Publication status	Published - Jul 2021

Keywords

breast cancer
cancer stem cells
citral
F127
Pluronic
polymeric micelles

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Pluronic F127 micelles improve the stability and enhance the anticancer stem cell efficacy of citral in breast cancer",

abstract = "Aim: Improving the stability and anti-cancer stem cell (CSC) activity of citral, a natural ALDH1A inhibitor. Materials & methods: Citral-loaded micelles (CLM) were obtained using Pluronic{\textregistered} F127 and its efficacy tested on the growth of four breast cancer cell lines. The impact of the CLM on the growth and functional hallmarks of breast CSCs were also evaluated using mammosphere and CSC reporter cell lines. Results: CLM improved the stability and growth inhibitory effects of citral. Importantly, CLM fully blocking the stemness features of CSCs (self-renewal, differentiation and migration) and in combination with paclitaxel CLM sensitized breast cancer cells to the chemotherapy. Conclusion: Targeting CSCs with CLM could improve the treatment of advanced breast cancer in combination with the standard chemotherapy.",

keywords = "breast cancer, cancer stem cells, citral, F127, Pluronic, polymeric micelles",

author = "Abu-Serie, {Marwa M.} and Fernanda Andrade and Patricia C{\'a}mara-S{\'a}nchez and Joaquin Seras-Franzoso and DIana Rafael and D{\'I}az-Riascos, {Zamira V.} and Petra Gener and Ibane Abasolo and Sim{\'o} Schwartz",

year = "2021",

month = jul,

doi = "10.2217/nnm-2021-0013",

language = "English",

volume = "16",

pages = "1471--1485",

journal = "Nanomedicine",

issn = "1743-5889",

publisher = "Future Medicine Ltd.",

number = "17",

}

TY - JOUR

T1 - Pluronic F127 micelles improve the stability and enhance the anticancer stem cell efficacy of citral in breast cancer

AU - Abu-Serie, Marwa M.

AU - Andrade, Fernanda

AU - Cámara-Sánchez, Patricia

AU - Seras-Franzoso, Joaquin

AU - Rafael, DIana

AU - DÍaz-Riascos, Zamira V.

AU - Gener, Petra

AU - Abasolo, Ibane

AU - Schwartz, Simó

PY - 2021/7

Y1 - 2021/7

N2 - Aim: Improving the stability and anti-cancer stem cell (CSC) activity of citral, a natural ALDH1A inhibitor. Materials & methods: Citral-loaded micelles (CLM) were obtained using Pluronic® F127 and its efficacy tested on the growth of four breast cancer cell lines. The impact of the CLM on the growth and functional hallmarks of breast CSCs were also evaluated using mammosphere and CSC reporter cell lines. Results: CLM improved the stability and growth inhibitory effects of citral. Importantly, CLM fully blocking the stemness features of CSCs (self-renewal, differentiation and migration) and in combination with paclitaxel CLM sensitized breast cancer cells to the chemotherapy. Conclusion: Targeting CSCs with CLM could improve the treatment of advanced breast cancer in combination with the standard chemotherapy.

AB - Aim: Improving the stability and anti-cancer stem cell (CSC) activity of citral, a natural ALDH1A inhibitor. Materials & methods: Citral-loaded micelles (CLM) were obtained using Pluronic® F127 and its efficacy tested on the growth of four breast cancer cell lines. The impact of the CLM on the growth and functional hallmarks of breast CSCs were also evaluated using mammosphere and CSC reporter cell lines. Results: CLM improved the stability and growth inhibitory effects of citral. Importantly, CLM fully blocking the stemness features of CSCs (self-renewal, differentiation and migration) and in combination with paclitaxel CLM sensitized breast cancer cells to the chemotherapy. Conclusion: Targeting CSCs with CLM could improve the treatment of advanced breast cancer in combination with the standard chemotherapy.

KW - breast cancer

KW - cancer stem cells

KW - citral

KW - F127

KW - Pluronic

KW - polymeric micelles

UR - http://www.scopus.com/inward/record.url?scp=85111787489&partnerID=8YFLogxK

U2 - 10.2217/nnm-2021-0013

DO - 10.2217/nnm-2021-0013

M3 - Article

C2 - 34160295

AN - SCOPUS:85111787489

SN - 1743-5889

VL - 16

SP - 1471

EP - 1485

JO - Nanomedicine

JF - Nanomedicine

IS - 17

ER -

Pluronic F127 micelles improve the stability and enhance the anticancer stem cell efficacy of citral in breast cancer

Abstract

Keywords

UN SDGs

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