Plasticity of the enteric nervous system during intestinal inflammation

A. E. Lomax, E. Fernández, Keith A. Sharkey

Research output: Contribution to journalReview articleResearchpeer-review

154 Citations (Scopus)


Inflammation of the bowel causes structural and functional changes to the enteric nervous system (ENS). While morphological alterations to the ENS are evident in some inflammatory conditions, it appears that relatively subtle modifications to the neurophysiology of enteric microcircuits may play a role in gastrointestinal (GI) dysfunction. These include changes to the excitability and synaptic properties of enteric neurones. The response of the ENS to inflammation varies according to the site and type of inflammation, with the functional consequences depending on the nature of the inflammatory stimulus. It has become clear that inflammation at one site can produce changes that occur at remotes sites in the GI tract. Immunohistochemical data from patients with inflammatory bowel disease (IBD) and animal models indicate that inflammation alters the neurochemical content of some functional classes of enteric neurones. A growing body of evidence supports an active role for enteric glia in neuronal and neuroimmune communication in the GI tract, particularly during inflammation. In conclusion, plasticity of the ENS is a feature of intestinal inflammation. Elucidation of the mechanisms whereby inflammation alters enteric neural control of GI functions may lead to novel treatments for IBD.
Original languageEnglish
Pages (from-to)4-15
JournalNeurogastroenterology and Motility
Issue number1
Publication statusPublished - 1 Feb 2005


  • Inflammatory bowel disease
  • Motility
  • Myenteric
  • Secretion
  • Submucosal


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