Plasma methadone concentrations as an indicator of opioid withdrawal symptoms and heroin use in a methadone maintenance program

Marta Torrens, Claudio Castillo, Lluís San, Enrique Del Moral, María L. González, Rafael De La Torre

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

Abstract

Plasma methadone concentrations and its main metabolite D,L-2- ethylidiene-1,5-dimethyl-3,5-diphenylpyrrolidine (EDDP) were determined in 93 patients under methadone maintenance treatment to assess their relationship with heroin use and opioid withdrawal symptoms. Neither plasma concentrations of methadone nor EDDP were significantly different when patients that used heroin in last 3 months were compared with those testing negative for this drug (methadone, 355 ± 217 versus 369 ± 216 ng/ml, t = 0.29, P = NS; EDDP, 49 ± 28 versus 54 ± 40 ng/ml, t = 0.51, P = NS). No correlation between opioid withdrawal scale scores and plasma concentrations of methadone (r = 0.02, P = NS) and EDDP (r = -0.14, P = NS) was found. Therapeutic drug monitoring during methadone maintenance seems to be useful for assessing compliance with treatment but not for predicting heroin use and subjective withdrawal symptoms.
Original languageEnglish
Pages (from-to)193-200
JournalDrug and Alcohol Dependence
Volume52
Issue number3
DOIs
Publication statusPublished - 1 Nov 1998

Keywords

  • Cocaine use
  • Heroin use
  • Methadone maintenance
  • Opioid withdrawal symptoms
  • Plasma EDDP concentrations
  • Plasma methadone concentrations
  • Treatment compliance

Fingerprint Dive into the research topics of 'Plasma methadone concentrations as an indicator of opioid withdrawal symptoms and heroin use in a methadone maintenance program'. Together they form a unique fingerprint.

Cite this