Plasma and faecal disposition kinetic of moxidectin after oral admnistration in horses

R. Pérez, I. Cabezas, C. Godoy, L. Rubilar, L. Díaz, L. Muñoz, M. Arboix, M. Alvinerie

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Abstract

A study was undertaken with the aim to study the plasma disposition kinetic and the faecal excretion profile of moxidectin after oral administration in horses. Five mixedbred saddle horses of 416.8 ± 49.5 kg body weight and positives to the nematodes' faecal eggs count were treated with an oral gel formulation of moxidectin (Equest® ) at doses of 0.4 mg/kg. Blood and faecal samples were collected before and at different times after treatment for a period of 75 days. After solid phase extraction and derivatization samples were analysed by high performance liquid chromatography (HPLC). Data were analysed by a computerised kinetic analysis. The limit of quantification of the method was 0.5 ng/mL and the drug was detected in the plasma between 30 min (33.9 ± 17.8 ng/mL) to 75 days post administration (0.3 ± 0.2 ng/mL). The analysis of pharmacokinetic parameters showed a short half life of absorption (t _ ab 0. 84± 0.5 h) and values of maximum concentration (Cmax) of 68.7 ± 24.1 ng/mL obtained at 0.117 ± 0.07 d (Tmax). The terminal half life of elimination (t _β) was 18.3 ± 3.2 d, which produces a delayed mean residence time (MRT of 19.6 ± 4.6 d). The area under the concentration time curve was 172.3 ± 51.2 ng · d / mL. The mean concentration of moxidectin in faeces ranged between 423.5 ± 570.7 ng/g at 24 h and 0.8 ± 0.8 ng/g 75 d after treatment. The mean maximum faecal concentration (Cmax) 5204.5± 916.5 ng/g was observed at 2.5 d post-treatment. It is concluded that moxidectin has a delayed period of permanency in the organism when it is administered by oral route in horses.
Original languageEnglish
Pages (from-to)77-88
JournalArchivos de Medicina Veterinaria
Volume33
Issue number1
Publication statusPublished - 1 Dec 2001

Keywords

  • Anthelmintics
  • Endectocides
  • Faeces
  • Horses
  • Moxidectin
  • Pharmacokinetics

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    Pérez, R., Cabezas, I., Godoy, C., Rubilar, L., Díaz, L., Muñoz, L., Arboix, M., & Alvinerie, M. (2001). Plasma and faecal disposition kinetic of moxidectin after oral admnistration in horses. Archivos de Medicina Veterinaria, 33(1), 77-88.