Placental angiogenic growth factors and uterine artery Doppler findings for characterization of different subsets in preeclampsia and in isolated intrauterine growth restriction

Fàtima Crispi, Carmen Domínguez, Elisa Llurba, Pilar Martín-Gallán, Luís Cabero, Eduard Gratacós

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182 Citations (Scopus)

Abstract

Objective: The purpose of this study was to evaluate possible relationships between placental markers and endothelial dysfunction in preeclampsia and intrauterine growth restriction. Study design: A prospective study was conducted in 76 patients with preeclampsia and 37 patients with intrauterine growth restriction that were classified as early onset (<34 weeks of gestational age) or late onset, and 40 control subjects. Plasma levels of placental growth factor, soluble fms-like tyrosine kinase-1, vascular cell adhesion molecule-1, and uterine artery Doppler indices were measured. Results: In early-onset preeclampsia and intrauterine growth restriction, placental growth factor was lower and soluble fms-like tyrosine kinase-1 and vascular cell adhesion molecule-1 higher than in control subjects, although all changes were more pronounced in preeclampsia. In late-onset preeclampsia, those patients with abnormal uterine artery Doppler indices had higher soluble fms-like tyrosine kinase-1 and vascular cell adhesion molecule-1 levels. Conclusion: Biochemical changes in early-onset preeclampsia and intrauterine growth restriction point to a common placental disorder and a state of endothelial dysfunction, which may require interaction with other factors to explain the maternal disease in preeclampsia. Data in late-onset preeclampsia suggest that a proportion of them may occur with minimal placental involvement. © 2006 Mosby, Inc. All rights reserved.
Original languageEnglish
Pages (from-to)201-207
JournalAmerican Journal of Obstetrics and Gynecology
Volume195
Issue number1
DOIs
Publication statusPublished - 1 Jul 2006

Keywords

  • Intrauterine growth restriction
  • Preeclampsia
  • Soluble fms-like tyrosine kinase-1
  • Uterine artery Doppler

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