Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell growth

G.P. Sapkota; A. Kieloch; J.M. Lizcano; S. Lain; J.S. Arthur; M.R. Williams; N. Morrice; M. Deak; D.R. Alessi

Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell growth

G.P. Sapkota, A. Kieloch, J.M. Lizcano, S. Lain, J.S. Arthur, M.R. Williams, N. Morrice, M. Deak, D.R. Alessi

Research output: Contribution to journal › Article › Research

Original language	English
Pages (from-to)	19469-19482
Journal	J. Biol. Chem.
Volume	276
Issue number	22
Publication status	Published - 1 Jun 2001

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Cite this

Sapkota, G. P., Kieloch, A., Lizcano, J. M., Lain, S., Arthur, J. S., Williams, M. R., Morrice, N., Deak, M., & Alessi, D. R. (2001). Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell growth. J. Biol. Chem., 276(22), 19469-19482.

Sapkota, G.P. ; Kieloch, A. ; Lizcano, J.M. ; Lain, S. ; Arthur, J.S. ; Williams, M.R. ; Morrice, N. ; Deak, M. ; Alessi, D.R. / Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell growth. In: J. Biol. Chem. 2001 ; Vol. 276, No. 22. pp. 19469-19482.

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title = "Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell growth",

author = "G.P. Sapkota and A. Kieloch and J.M. Lizcano and S. Lain and J.S. Arthur and M.R. Williams and N. Morrice and M. Deak and D.R. Alessi",

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pages = "19469--19482",

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Sapkota, GP, Kieloch, A, Lizcano, JM, Lain, S, Arthur, JS, Williams, MR, Morrice, N, Deak, M & Alessi, DR 2001, 'Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell growth', J. Biol. Chem., vol. 276, no. 22, pp. 19469-19482.

Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell growth. / Sapkota, G.P.; Kieloch, A.; Lizcano, J.M.; Lain, S.; Arthur, J.S.; Williams, M.R.; Morrice, N.; Deak, M.; Alessi, D.R.

In: J. Biol. Chem., Vol. 276, No. 22, 01.06.2001, p. 19469-19482.

Research output: Contribution to journal › Article › Research

TY - JOUR

T1 - Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell growth

AU - Sapkota, G.P.

AU - Kieloch, A.

AU - Lizcano, J.M.

AU - Lain, S.

AU - Arthur, J.S.

AU - Williams, M.R.

AU - Morrice, N.

AU - Deak, M.

AU - Alessi, D.R.

PY - 2001/6/1

Y1 - 2001/6/1

M3 - Article

VL - 276

SP - 19469

EP - 19482

IS - 22

ER -