TY - JOUR
T1 - Phenotypic Description of the Spanish Multicentre Genetic Glaucoma Group Cohort
AU - Milla, Elena
AU - Gamundi, Maria José
AU - Duch, Susana
AU - Rios, Jose
AU - Carballo, Miguel
AU - Study Group, Emeigg
N1 - Publisher Copyright:
© 2017 Elena Milla et al.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2017
Y1 - 2017
N2 - Introduction. The aim of the study was to make a phenotypic description of the Spanish multicentre glaucoma group cohort of patients. Design. Retrospective, observational, multicentre, cohort study. Material and Methods. The clinical charts of 152 patients with hereditary glaucoma from18 Spanish eye centres were reviewed in order to make an epidemiologic description of the type of glaucoma and associated factors. True hereditary cases were compared with familiar cases according to the Gong et al. criteria. Results. 61% were true hereditary cases and 39% familiar cases. Ocular comorbidity, optic disc damage, and visual field mean defect were significantly more severe in hereditary patients, who required significantly more first-line hypotensive drugs and surgical interventions to control intraocular pressure than familiar patients. Conclusions. The strength of the hereditary component of glaucoma seems to worsen the clinical course, causing more structural and functional damage and requiring more intense glaucoma treatment. The family history of glaucoma should be carefully investigated and taken into consideration when making treatment decisions or intensifying previous treatment.
AB - Introduction. The aim of the study was to make a phenotypic description of the Spanish multicentre glaucoma group cohort of patients. Design. Retrospective, observational, multicentre, cohort study. Material and Methods. The clinical charts of 152 patients with hereditary glaucoma from18 Spanish eye centres were reviewed in order to make an epidemiologic description of the type of glaucoma and associated factors. True hereditary cases were compared with familiar cases according to the Gong et al. criteria. Results. 61% were true hereditary cases and 39% familiar cases. Ocular comorbidity, optic disc damage, and visual field mean defect were significantly more severe in hereditary patients, who required significantly more first-line hypotensive drugs and surgical interventions to control intraocular pressure than familiar patients. Conclusions. The strength of the hereditary component of glaucoma seems to worsen the clinical course, causing more structural and functional damage and requiring more intense glaucoma treatment. The family history of glaucoma should be carefully investigated and taken into consideration when making treatment decisions or intensifying previous treatment.
UR - http://www.scopus.com/inward/record.url?scp=85031940338&partnerID=8YFLogxK
U2 - 10.1155/2017/1907454
DO - 10.1155/2017/1907454
M3 - Artículo
AN - SCOPUS:85031940338
VL - 2017
JO - Journal of Ophthalmology
JF - Journal of Ophthalmology
SN - 2090-004X
M1 - 1907454
ER -