Phenobarbiturate Flow-through Electrode for Flow Injection Analysis of Pharmaceutical Products

Jose L.F.C. Lima, M. Conceigao B.S.M. Montenegro, J. Alonso-Chamarro, J. Bartroli, J. Garcia-Raurich

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10 Citations (Scopus)

Abstract

We constructed, tested and applied a tubular 5-ethyl-5-phenylbarbiturate ion-selective electrode based on tetraoctylammonium 5-ethyl-5-phenylbarbiturate dissolved in o-nitrophenyl octyl ether and immobilized on poly(vinyl chloride). The intrinsic features of the proposed electrode were assessed by using a low-dispersion single-channel flow injection analysis (FIA) system for performing repeated calibrations with sodium 5-ethyl-5-phenylbarbiturate standards, whose ionic strength was adjusted to 0.1 M with 0.033 M sodium sulfate. The determination of 5-ethyl-5- phenylbarbiturate in pharmaceutical preparations was accomplished by intercalating the proposed electrode into a twochannel FIA manifold. The results obtained were compared with those provided by the British Pharmacopoeia standard method. © 1992, The Japan Society for Analytical Chemistry. All rights reserved.
Original languageEnglish
Pages (from-to)19-23
JournalAnalytical Sciences
Volume8
Issue number1
DOIs
Publication statusPublished - 1 Jan 1992

Keywords

  • 5-ethyl-5-phenylbarbiturate
  • Flow injection analysis
  • pharmaceutical preparation
  • tubular ion-selective electrode

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