Phenobarbiturate Flow-through Electrode for Flow Injection Analysis of Pharmaceutical Products

Jose L.F.C. Lima; M. Conceigao B.S.M. Montenegro; J. Alonso-Chamarro; J. Bartroli; J. Garcia-Raurich

doi:10.2116/analsci.8.19

Phenobarbiturate Flow-through Electrode for Flow Injection Analysis of Pharmaceutical Products

Jose L.F.C. Lima, M. Conceigao B.S.M. Montenegro, J. Alonso-Chamarro, J. Bartroli, J. Garcia-Raurich

Department of Chemistry

Research output: Contribution to journal › Article › Research › peer-review

10 Citations (Scopus)

Abstract

We constructed, tested and applied a tubular 5-ethyl-5-phenylbarbiturate ion-selective electrode based on tetraoctylammonium 5-ethyl-5-phenylbarbiturate dissolved in o-nitrophenyl octyl ether and immobilized on poly(vinyl chloride). The intrinsic features of the proposed electrode were assessed by using a low-dispersion single-channel flow injection analysis (FIA) system for performing repeated calibrations with sodium 5-ethyl-5-phenylbarbiturate standards, whose ionic strength was adjusted to 0.1 M with 0.033 M sodium sulfate. The determination of 5-ethyl-5- phenylbarbiturate in pharmaceutical preparations was accomplished by intercalating the proposed electrode into a twochannel FIA manifold. The results obtained were compared with those provided by the British Pharmacopoeia standard method. © 1992, The Japan Society for Analytical Chemistry. All rights reserved.

Original language	English
Pages (from-to)	19-23
Journal	Analytical Sciences
Volume	8
Issue number	1
DOIs	https://doi.org/10.2116/analsci.8.19
Publication status	Published - 1 Jan 1992

Keywords

5-ethyl-5-phenylbarbiturate
Flow injection analysis
pharmaceutical preparation
tubular ion-selective electrode

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@article{7f996a693ac44ffd96459afecec155c1,

title = "Phenobarbiturate Flow-through Electrode for Flow Injection Analysis of Pharmaceutical Products",

abstract = "We constructed, tested and applied a tubular 5-ethyl-5-phenylbarbiturate ion-selective electrode based on tetraoctylammonium 5-ethyl-5-phenylbarbiturate dissolved in o-nitrophenyl octyl ether and immobilized on poly(vinyl chloride). The intrinsic features of the proposed electrode were assessed by using a low-dispersion single-channel flow injection analysis (FIA) system for performing repeated calibrations with sodium 5-ethyl-5-phenylbarbiturate standards, whose ionic strength was adjusted to 0.1 M with 0.033 M sodium sulfate. The determination of 5-ethyl-5- phenylbarbiturate in pharmaceutical preparations was accomplished by intercalating the proposed electrode into a twochannel FIA manifold. The results obtained were compared with those provided by the British Pharmacopoeia standard method. {\textcopyright} 1992, The Japan Society for Analytical Chemistry. All rights reserved.",

keywords = "5-ethyl-5-phenylbarbiturate, Flow injection analysis, pharmaceutical preparation, tubular ion-selective electrode",

author = "Lima, {Jose L.F.C.} and Montenegro, {M. Conceigao B.S.M.} and J. Alonso-Chamarro and J. Bartroli and J. Garcia-Raurich",

year = "1992",

month = jan,

day = "1",

doi = "10.2116/analsci.8.19",

language = "English",

volume = "8",

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TY - JOUR

T1 - Phenobarbiturate Flow-through Electrode for Flow Injection Analysis of Pharmaceutical Products

AU - Lima, Jose L.F.C.

AU - Montenegro, M. Conceigao B.S.M.

AU - Alonso-Chamarro, J.

AU - Bartroli, J.

AU - Garcia-Raurich, J.

PY - 1992/1/1

Y1 - 1992/1/1

N2 - We constructed, tested and applied a tubular 5-ethyl-5-phenylbarbiturate ion-selective electrode based on tetraoctylammonium 5-ethyl-5-phenylbarbiturate dissolved in o-nitrophenyl octyl ether and immobilized on poly(vinyl chloride). The intrinsic features of the proposed electrode were assessed by using a low-dispersion single-channel flow injection analysis (FIA) system for performing repeated calibrations with sodium 5-ethyl-5-phenylbarbiturate standards, whose ionic strength was adjusted to 0.1 M with 0.033 M sodium sulfate. The determination of 5-ethyl-5- phenylbarbiturate in pharmaceutical preparations was accomplished by intercalating the proposed electrode into a twochannel FIA manifold. The results obtained were compared with those provided by the British Pharmacopoeia standard method. © 1992, The Japan Society for Analytical Chemistry. All rights reserved.

AB - We constructed, tested and applied a tubular 5-ethyl-5-phenylbarbiturate ion-selective electrode based on tetraoctylammonium 5-ethyl-5-phenylbarbiturate dissolved in o-nitrophenyl octyl ether and immobilized on poly(vinyl chloride). The intrinsic features of the proposed electrode were assessed by using a low-dispersion single-channel flow injection analysis (FIA) system for performing repeated calibrations with sodium 5-ethyl-5-phenylbarbiturate standards, whose ionic strength was adjusted to 0.1 M with 0.033 M sodium sulfate. The determination of 5-ethyl-5- phenylbarbiturate in pharmaceutical preparations was accomplished by intercalating the proposed electrode into a twochannel FIA manifold. The results obtained were compared with those provided by the British Pharmacopoeia standard method. © 1992, The Japan Society for Analytical Chemistry. All rights reserved.

KW - 5-ethyl-5-phenylbarbiturate

KW - Flow injection analysis

KW - pharmaceutical preparation

KW - tubular ion-selective electrode

U2 - 10.2116/analsci.8.19

DO - 10.2116/analsci.8.19

M3 - Article

VL - 8

SP - 19

EP - 23

IS - 1

ER -