Pharmacokinetics of indomethacin in poultry

C. Cristòfol, J. E. Valladares, G. Martí, M. Arboix

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Abstract

Indomethacin (INDO) is a nonsteroidal antiinflammatory drug widely used since the 1970s. The pharmacokinetic behavior of INDO (2 mg/kg) has been studied after intravenous (IV) and oral administration to broiler chickens. After IV administration, a first fast distribution phase and a later and slower elimination phase were observed. The elimination half-life and mean residence time (MRT) obtained were 1.0 hr and 0.8 hr, respectively. After oral administration, a flip-flop phenomenon was observed giving an elimination half-life and MRT approximately three times and six times higher, respectively, than the IV administration. The plasma concentrations after oral administration were sustained during 8-10 hr, giving an antinflammatory cover over the dose producing 50% of maximal effect during this time period.
Original languageEnglish
Pages (from-to)210-214
JournalAvian Diseases
Volume44
Issue number1
DOIs
Publication statusPublished - 1 Jan 2000

Keywords

  • Broiler
  • Disposition
  • Indomethacin
  • Pharmacokinetics
  • Plasma concentrations
  • Poultry

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