Pharmacokinetics of buprenorphine after intravenous administration of clinical doses to dogs

Anna Andaluz, Xavier Moll, Rosario Abellán, Rosa Ventura, Marcellí Carbó, Laura Fresno, Félix García

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Abstract

The purpose of this study was to evaluate plasma concentrations and pharmacokinetic parameters of buprenorphine in dogs following intravenous (IV) administration of clinical doses of the opioid. An IV bolus of 0.02 mg/kg buprenorphine was administered to six healthy Beagles and blood samples were collected through a jugular catheter before and at 1, 5, 10, 15, 20, 30 and 45 min, and 1, 2, 4, 6, 8 and 12 h after administration. Plasma buprenorphine concentrations, measured using a commercial radioimmunoassay (RIA), decreased following a three-exponential curve. The two distribution and the elimination half-lives were 2.9 ± 1.8 min, 16.5 ± 3.7 min, and 266.6 ± 82.0 min, respectively; the clearance was 329.6 ± 62.2 mL/min, and the steady state volume of distribution was 83.7 ± 26.5 L. The results demonstrated the feasibility of the RIA assay to analyse buprenorphine in dog plasma samples. Following IV administration buprenorphine showed a three-compartment kinetic profile, as has been described previously in humans, rabbits and cats. The relationship between plasma concentrations and dynamic effects in dogs remains to be established. © 2008 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)299-304
JournalVeterinary Journal
Volume181
Issue number3
DOIs
Publication statusPublished - 1 Sep 2009

Keywords

  • Buprenorphine
  • Dogs
  • Intravenous
  • Pharmacokinetics
  • Radioimmunoassay

Fingerprint Dive into the research topics of 'Pharmacokinetics of buprenorphine after intravenous administration of clinical doses to dogs'. Together they form a unique fingerprint.

Cite this