TY - JOUR
T1 - Pharmacokinetics of albendazole sulfoxide enantiomers administered in racemic form and separately in rats
AU - Capece, BPS
AU - Castells Carles, Glòria
AU - Godoy Olivares, Carlo Mauricio
AU - Arboix Arzo, Margarita
AU - Cristòfol Adell, Carles
PY - 2008/8
Y1 - 2008/8
N2 - The pharmacokinetic behaviour of albendazole sulfoxide (ABZSO) enantiomers was studied in rats after the oral administration of 10 mg/kg of rac-ABZSO, 5 mg/kg of (−)-ABZSO or 5 mg/kg of (+)-ABZSO. The disposition profiles of ABZSO enantiomers were similar in all treatments, but the calculated area under the curve for the (−)-ABZSO was higher in all cases compared with (+)-ABZSO. The results suggest that there is no chiral inversion of ABZSO enantiomers. After the administration of rac-ABZSO, 17.2% of the total dose was recovered in urine as albendazole ABZ (0.1%), albendazole sulfone ABZSO2 (0.3%), albendazole 2-aminosulfone (ABZ-SO2NH2) (3.1%) and ABZSO (13.7%). The ratio (+) to (−) was similar in urine (1.6) and blood (1.7).
AB - The pharmacokinetic behaviour of albendazole sulfoxide (ABZSO) enantiomers was studied in rats after the oral administration of 10 mg/kg of rac-ABZSO, 5 mg/kg of (−)-ABZSO or 5 mg/kg of (+)-ABZSO. The disposition profiles of ABZSO enantiomers were similar in all treatments, but the calculated area under the curve for the (−)-ABZSO was higher in all cases compared with (+)-ABZSO. The results suggest that there is no chiral inversion of ABZSO enantiomers. After the administration of rac-ABZSO, 17.2% of the total dose was recovered in urine as albendazole ABZ (0.1%), albendazole sulfone ABZSO2 (0.3%), albendazole 2-aminosulfone (ABZ-SO2NH2) (3.1%) and ABZSO (13.7%). The ratio (+) to (−) was similar in urine (1.6) and blood (1.7).
KW - Albendazole sulfoxide
KW - Enantiomers
KW - Rats
KW - Pharmacokinetics
KW - Enantioselectivity
U2 - 10.1016/j.tvjl.2007.04.011
DO - 10.1016/j.tvjl.2007.04.011
M3 - Article
SN - 1090-0233
VL - 177
SP - 297
EP - 299
JO - Veterinary Journal
JF - Veterinary Journal
IS - 2
ER -