Pharmacokinetics of albendazole sulfoxide enantiomers administered in racemic form and separately in rats

Bettencourt P.S. Capece, Gloria Castells, Carlo Godoy, Margarita Arboix, Carles Cristòfol

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Abstract

The pharmacokinetic behaviour of albendazole sulfoxide (ABZSO) enantiomers was studied in rats after the oral administration of 10 mg/kg of rac-ABZSO, 5 mg/kg of (-)-ABZSO or 5 mg/kg of (+)-ABZSO. The disposition profiles of ABZSO enantiomers were similar in all treatments, but the calculated area under the curve for the (-)-ABZSO was higher in all cases compared with (+)-ABZSO. The results suggest that there is no chiral inversion of ABZSO enantiomers. After the administration of rac-ABZSO, 17.2% of the total dose was recovered in urine as albendazole ABZ (0.1%), albendazole sulfone ABZSO2 (0.3%), albendazole 2-aminosulfone (ABZ-SO2NH2) (3.1%) and ABZSO (13.7%). The ratio (+) to (-) was similar in urine (1.6) and blood (1.7). © 2007 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)297-299
JournalVeterinary Journal
Volume177
DOIs
Publication statusPublished - 1 Aug 2008

Keywords

  • Albendazole sulfoxide
  • Enantiomers
  • Enantioselectivity
  • Pharmacokinetics
  • Rats

Fingerprint Dive into the research topics of 'Pharmacokinetics of albendazole sulfoxide enantiomers administered in racemic form and separately in rats'. Together they form a unique fingerprint.

Cite this