Abstract
The pharmacokinetic behaviour of albendazole sulfoxide (ABZSO) enantiomers was studied in rats after the oral administration of 10 mg/kg of rac-ABZSO, 5 mg/kg of (-)-ABZSO or 5 mg/kg of (+)-ABZSO. The disposition profiles of ABZSO enantiomers were similar in all treatments, but the calculated area under the curve for the (-)-ABZSO was higher in all cases compared with (+)-ABZSO. The results suggest that there is no chiral inversion of ABZSO enantiomers. After the administration of rac-ABZSO, 17.2% of the total dose was recovered in urine as albendazole ABZ (0.1%), albendazole sulfone ABZSO2 (0.3%), albendazole 2-aminosulfone (ABZ-SO2NH2) (3.1%) and ABZSO (13.7%). The ratio (+) to (-) was similar in urine (1.6) and blood (1.7). © 2007 Elsevier Ltd. All rights reserved.
Original language | English |
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Pages (from-to) | 297-299 |
Journal | Veterinary Journal |
Volume | 177 |
DOIs | |
Publication status | Published - 1 Aug 2008 |
Keywords
- Albendazole sulfoxide
- Enantiomers
- Enantioselectivity
- Pharmacokinetics
- Rats