Pharmacokinetic Comparison of Soy Isoflavone Extracts in Human Plasma

Jose Rodríguez-Morató, Magí Farré, Clara Pérez-Maná, Esther Papaseit, Roser Martínez-Riera, Rafael De La Torre, Nieves Pizarro

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Abstract

© 2015 American Chemical Society. The soy isoflavones daidzein and genistein produce several biological activities related to health benefits. A number of isoflavone extracts are commercially available, but there is little information concerning the specific isoflavone content of these products or differences in their bioavailability and pharmacokinetics. This study describes the development and validation of an analytical method to detect and quantify daidzein, genistein, and equol in human plasma using liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS). The method was applied in a crossover, randomized, bioavailability study. Twelve healthy volunteers were administered the same total isoflavones dose from two isoflavone supplement preparations (Super-Absorbable Soy Isoflavones (Life Extension, USA) and Fitoladius (Merck, ESP)). The pharmacokinetic parameters (AUC<inf>0-24</inf>/dose and C<inf>max</inf>/dose) of the isoflavones from the two preparations differed significantly. Such differences in bioavailability and kinetics may have relevant effects on the health benefits derived from their intake.
Original languageEnglish
Pages (from-to)6946-6953
JournalJournal of Agricultural and Food Chemistry
Volume63
Issue number31
DOIs
Publication statusPublished - 12 Aug 2015

Keywords

  • bioavailability
  • clinical trial
  • daidzein
  • equol
  • genistein
  • pharmacokinetics
  • Soy isoflavone extracts

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