pH-Responsive Relaxometric Behaviour of Coordination Polymer Nanoparticles Made of a Stable Macrocyclic Gadolinium Chelate

Javier Aríñez-Soriano, Jorge Albalad, Arnau Carné-Sánchez, Célia S. Bonnet, Félix Busqué, Julia Lorenzo, Jordi Juanhuix, Maxwell W. Terban, Inhar Imaz, Éva Tóth, Daniel Maspoch

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3 Citations (Scopus)

Abstract

© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Lanthanide-containing nanoscale particles have been widely explored for various biomedical purposes, however, they are often prone to metal leaching. Here we have created a new coordination polymer (CP) by applying, for the first time, a stable GdIIIchelate as building block in order to prevent any fortuitous release of free lanthanide(III) ion. The use of the Gd-DOTA-4AmP complex as a design element in the CP allows not only for enhanced relaxometric properties (maximum r1=16.4 mm−1s−1at 10 MHz), but also for a pH responsiveness (Δr1=108 % between pH 4 and 6.5), beyond the values obtained for the low molecular weight Gd-DOTA-4AmP itself. The CP can be miniaturised to the nanoscale to form colloids that are stable in physiological saline solution and in cell culture media and does not show cytotoxicity.
Original languageEnglish
Pages (from-to)13162-13170
JournalChemistry - A European Journal
Volume22
Issue number37
DOIs
Publication statusPublished - 1 Jan 2016

Keywords

  • chelates
  • contrast agents
  • coordination polymers
  • gadolinium
  • relaxometry

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    Aríñez-Soriano, J., Albalad, J., Carné-Sánchez, A., Bonnet, C. S., Busqué, F., Lorenzo, J., Juanhuix, J., Terban, M. W., Imaz, I., Tóth, É., & Maspoch, D. (2016). pH-Responsive Relaxometric Behaviour of Coordination Polymer Nanoparticles Made of a Stable Macrocyclic Gadolinium Chelate. Chemistry - A European Journal, 22(37), 13162-13170. https://doi.org/10.1002/chem.201602356