TY - JOUR
T1 - pH-Responsive Relaxometric Behaviour of Coordination Polymer Nanoparticles Made of a Stable Macrocyclic Gadolinium Chelate
AU - Aríñez-Soriano, Javier
AU - Albalad, Jorge
AU - Carné-Sánchez, Arnau
AU - Bonnet, Célia S.
AU - Busqué, Félix
AU - Lorenzo, Julia
AU - Juanhuix, Jordi
AU - Terban, Maxwell W.
AU - Imaz, Inhar
AU - Tóth, Éva
AU - Maspoch, Daniel
PY - 2016/1/1
Y1 - 2016/1/1
N2 - © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Lanthanide-containing nanoscale particles have been widely explored for various biomedical purposes, however, they are often prone to metal leaching. Here we have created a new coordination polymer (CP) by applying, for the first time, a stable GdIIIchelate as building block in order to prevent any fortuitous release of free lanthanide(III) ion. The use of the Gd-DOTA-4AmP complex as a design element in the CP allows not only for enhanced relaxometric properties (maximum r1=16.4 mm−1s−1at 10 MHz), but also for a pH responsiveness (Δr1=108 % between pH 4 and 6.5), beyond the values obtained for the low molecular weight Gd-DOTA-4AmP itself. The CP can be miniaturised to the nanoscale to form colloids that are stable in physiological saline solution and in cell culture media and does not show cytotoxicity.
AB - © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Lanthanide-containing nanoscale particles have been widely explored for various biomedical purposes, however, they are often prone to metal leaching. Here we have created a new coordination polymer (CP) by applying, for the first time, a stable GdIIIchelate as building block in order to prevent any fortuitous release of free lanthanide(III) ion. The use of the Gd-DOTA-4AmP complex as a design element in the CP allows not only for enhanced relaxometric properties (maximum r1=16.4 mm−1s−1at 10 MHz), but also for a pH responsiveness (Δr1=108 % between pH 4 and 6.5), beyond the values obtained for the low molecular weight Gd-DOTA-4AmP itself. The CP can be miniaturised to the nanoscale to form colloids that are stable in physiological saline solution and in cell culture media and does not show cytotoxicity.
KW - chelates
KW - contrast agents
KW - coordination polymers
KW - gadolinium
KW - relaxometry
U2 - 10.1002/chem.201602356
DO - 10.1002/chem.201602356
M3 - Article
SN - 0947-6539
VL - 22
SP - 13162
EP - 13170
JO - Chemistry - A European Journal
JF - Chemistry - A European Journal
IS - 37
ER -