Aim. The aim of this paper was to prospectively evaluate FDG PET/CT in the assessment of metabolic response to neoadjuvant chemotherapy and correlation with tumor cellularity in locally advanced breast cancer.
Methods. Images were acquired with a PET/CT scanner in 50 patients at baseline and after completion of treatment, just before surgery. All findings were confirmed by histopathological analysis. PET/CT quantification (SUVmax) at baseline and after finishing neoadjuvant chemotherapy (4 cycles of epirubicin + cyclophosphamide +/- taxanes) were compared using RECIST criteria and Miller & Payne (M&P) scale.
Results. Baseline mean tumor size was 4.4 +/- 1.6 cm. Thirty eight patients were considered responders and 12 nonresponders. According to M&P scale, 10 patients had good prognosis (grades 4-5) and 40 patients had bad prognosis (grades 1-3). All patients with grade 5 M&P had no significant postchemotherapy FDG uptake. Patients with bad prognosis had lower SUVmax variation (Delta SUVmax) than patients with good prognosis (60.7% vs. 80.5%, P=0.0016). Delta SUVmax was lower in nonresponders than in partial responders according to RECIST criteria (38.9% vs. 67.6%, p45 to 82) showed an overall accuracy of 78% (Weighted Kappa=0.74).
Conclusion. PET/CT is useful to monitor response to neoadjuvant chemotherapy in locally advanced breast cancer. Delta SUVmax on PET/CT correlates with tumor cellularity after completion of neoadjuvant chemotherapy.
|Number of pages||8|
|Journal||Q J Nucl Med Imaging|
|Publication status||Published - Jun 2012|
- Breast neoplasms
- Positron-emission tomography
- X-ray, computed tomography
- CELL LUNG-CANCER
- PREOPERATIVE CHEMOTHERAPY
- PATHOLOGICAL RESPONSE
- F-18-FDG PET
- TUMOR RESPONSE