Personality, amphetamine and intracranial self-stimulation in rats

Ignacio Morgado-Bernal, Lluis Garcia-Sevilla

    Research output: Contribution to journalArticleResearchpeer-review

    1 Citation (Scopus)


    The relationship between open-field ambulation and intracranial self-stimulation (ICSS) at the lateral hypothalamic area was studied in rats. A treatment with i.p. saline of d-amphetamine was also applied to the animals prior to ICSS tests. High-ambulatory rats (comparable to human extraverts) showed an equally higher susceptibility to ICSS reward than low-ambulatory rats (comparable to human introverts) with both saline and amphetamine. These findings were interpreted comsidering the ICSS as a strong stimulation which would tend to produce 'unconditioned inhibition' much earlier in low-ambulatory rats than high-ambulatory rats thus leading to a better conditioning among the high-ambulatory Ss. © 1985.
    Original languageEnglish
    Pages (from-to)137-140
    JournalPersonality and Individual Differences
    Issue number1
    Publication statusPublished - 1 Jan 1985


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