Perseverance of exploration in novel environments predicts morphine place conditioning in rats

R. Nadal, D. Rotllant, C. Márquez, A. Armario

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27 Citations (Scopus)


Reactivity to novelty has been related to operant drug self-administration but does not seem involved in the conditioned place preference (CPP). To further assess this issue our aims were to investigate: (1) the importance of the initial versus delayed activity in the novel environment to predict the CPP induced by morphine; (2) the separate contribution of trait anxiety in morphine CPP. Male Sprague-Dawley rats were exposed to a circular corridor for 30 min to assess reactivity to novelty and to the elevated plus-maze and the light-dark tests as measures of anxiety and morphine CPP was then studied (three pairings with 5 mg/kg s.c. morphine and three with saline). Delayed activity in the corridor (16-30 min) correlated positively with CPP score, whereas the initial activity (0-15 min) did not. High-responders (HR), those more active during the second half of the corridor, developed morphine CPP in contrast to low-responders (LR). Also, HR and LR did not differ in anxiety nor any plus-maze or light-dark test measure correlated with CPP behaviour. Enhanced vulnerability to develop morphine CPP is predicted by a higher delayed activity in a novel environment, regardless of anxiety. © 2005 Elsevier B.V. All rights reserved.
Original languageEnglish
Pages (from-to)72-79
JournalBehavioural Brain Research
Issue number1
Publication statusPublished - 30 Nov 2005


  • Addiction
  • Anxiety
  • Individual differences
  • Locomotor activity
  • Place conditioning
  • Response to novelty
  • Reward


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