Peripheral blood non-MAIT CD8+CD161hi cells are decreased in relapsing-remitting multiple sclerosis patients treated with interferon beta

Laura Negrotto; Ester Cantó; Jordi Río; Mar Tintoré; Xavier Montalban; Manuel Comabella

doi:10.1016/j.jneuroim.2015.09.007

Peripheral blood non-MAIT CD8+CD161hi cells are decreased in relapsing-remitting multiple sclerosis patients treated with interferon beta

Laura Negrotto, Ester Cantó, Jordi Río, Mar Tintoré, Xavier Montalban, Manuel Comabella

Department of Medicine

Research output: Contribution to journal › Article › Research › peer-review

6 Citations (Scopus)

Abstract

© 2015 Elsevier B.V. CD8 + CD161hi cells, comprising MAIT and non-MAIT cells, have been involved in multiple sclerosis (MS) pathogenesis. Here, we investigated the frequency of CD8 + CD161hi, MAIT and non-MAIT cells by flow cytometry in peripheral blood samples from 41 untreated MS patients, 48 patients receiving disease modifying therapies, and 17 healthy controls (HC). IFNβ treatment was associated with a decrease in the frequency of Tc17 cells compared to untreated patients (p = 0.019). No significant differences were observed between untreated MS patients and HC for any of the study cell populations. These results suggest previously unknown mechanisms of action of IFNβ.

Original language	English
Pages (from-to)	98-101
Journal	Journal of Neuroimmunology
Volume	288
DOIs	https://doi.org/10.1016/j.jneuroim.2015.09.007
Publication status	Published - 1 Jan 2015

Keywords

CD161
CD8+CD161hi
Immunomodulatory treatments
Interleukin-17
Mucosal-associated invariant T cells
Multiple sclerosis
Tc17

Access to Document

10.1016/j.jneuroim.2015.09.007

Cite this

@article{309f2328c5594bc997d688567bae446a,

title = "Peripheral blood non-MAIT CD8+CD161hi cells are decreased in relapsing-remitting multiple sclerosis patients treated with interferon beta",

abstract = "{\textcopyright} 2015 Elsevier B.V. CD8 + CD161hi cells, comprising MAIT and non-MAIT cells, have been involved in multiple sclerosis (MS) pathogenesis. Here, we investigated the frequency of CD8 + CD161hi, MAIT and non-MAIT cells by flow cytometry in peripheral blood samples from 41 untreated MS patients, 48 patients receiving disease modifying therapies, and 17 healthy controls (HC). IFNβ treatment was associated with a decrease in the frequency of Tc17 cells compared to untreated patients (p = 0.019). No significant differences were observed between untreated MS patients and HC for any of the study cell populations. These results suggest previously unknown mechanisms of action of IFNβ.",

keywords = "CD161, CD8+CD161hi, Immunomodulatory treatments, Interleukin-17, Mucosal-associated invariant T cells, Multiple sclerosis, Tc17",

author = "Laura Negrotto and Ester Cant{\'o} and Jordi R{\'i}o and Mar Tintor{\'e} and Xavier Montalban and Manuel Comabella",

year = "2015",

month = jan,

day = "1",

doi = "10.1016/j.jneuroim.2015.09.007",

language = "English",

volume = "288",

pages = "98--101",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

}

TY - JOUR

T1 - Peripheral blood non-MAIT CD8+CD161hi cells are decreased in relapsing-remitting multiple sclerosis patients treated with interferon beta

AU - Negrotto, Laura

AU - Cantó, Ester

AU - Río, Jordi

AU - Tintoré, Mar

AU - Montalban, Xavier

AU - Comabella, Manuel

PY - 2015/1/1

Y1 - 2015/1/1

N2 - © 2015 Elsevier B.V. CD8 + CD161hi cells, comprising MAIT and non-MAIT cells, have been involved in multiple sclerosis (MS) pathogenesis. Here, we investigated the frequency of CD8 + CD161hi, MAIT and non-MAIT cells by flow cytometry in peripheral blood samples from 41 untreated MS patients, 48 patients receiving disease modifying therapies, and 17 healthy controls (HC). IFNβ treatment was associated with a decrease in the frequency of Tc17 cells compared to untreated patients (p = 0.019). No significant differences were observed between untreated MS patients and HC for any of the study cell populations. These results suggest previously unknown mechanisms of action of IFNβ.

AB - © 2015 Elsevier B.V. CD8 + CD161hi cells, comprising MAIT and non-MAIT cells, have been involved in multiple sclerosis (MS) pathogenesis. Here, we investigated the frequency of CD8 + CD161hi, MAIT and non-MAIT cells by flow cytometry in peripheral blood samples from 41 untreated MS patients, 48 patients receiving disease modifying therapies, and 17 healthy controls (HC). IFNβ treatment was associated with a decrease in the frequency of Tc17 cells compared to untreated patients (p = 0.019). No significant differences were observed between untreated MS patients and HC for any of the study cell populations. These results suggest previously unknown mechanisms of action of IFNβ.

KW - CD161

KW - CD8+CD161hi

KW - Immunomodulatory treatments

KW - Interleukin-17

KW - Mucosal-associated invariant T cells

KW - Multiple sclerosis

KW - Tc17

U2 - 10.1016/j.jneuroim.2015.09.007

DO - 10.1016/j.jneuroim.2015.09.007

M3 - Article

SN - 0165-5728

VL - 288

SP - 98

EP - 101

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

ER -

Peripheral blood non-MAIT CD8+CD161hi cells are decreased in relapsing-remitting multiple sclerosis patients treated with interferon beta

Abstract

Keywords

Access to Document

Fingerprint

Cite this