Periostin as a marker of Th2-related inflammation in patients with different types of chronic obstructive airway disease

Luis Perez de Llano; Fco De Borja Garcia-Cosio Piqueras; Irina Bobolea; Natividad de las Cuevas; Jose Luis LoPez-Campos; Vicente Plaza; Antolin Lopez-Vina; Alfons Torrego; Eva Martinez Moragon; Jose Luis Izquierdo; Javier Callejas; Joan Soriano; Marc Miravitlles; Juan Jose Soler-Catalunya

doi:10.1183/1393003.congress-2017.PA3978

Periostin as a marker of Th2-related inflammation in patients with different types of chronic obstructive airway disease

Luis Perez de Llano, Fco De Borja Garcia-Cosio Piqueras, Irina Bobolea, Natividad de las Cuevas, Jose Luis LoPez-Campos, Vicente Plaza, Antolin Lopez-Vina, Alfons Torrego, Eva Martinez Moragon, Jose Luis Izquierdo, Javier Callejas, Joan Soriano, Marc Miravitlles, Juan Jose Soler-Catalunya

Department of Medicine

Research output: Contribution to journal › Literature review › Research › peer-review

Abstract

Introduction: Periostin is a putative biomarker of T2 inflammatory response in asthma, with limited data in other chronic obstructive airway diseases (COAD), such as Asthma COPD Overlap (ACO).

Objectives: We aimed to investigate the value of periostin among different phenotypes of COAD, its correlation with other T2 biomarkers and its role in predicting a T2 inflammatory pattern.

Methods: Cross-sectional study of patients older than 40 years with a post-bronchodilator FEV1/FVC200UI/mcl, asthma with a smoking exposure (SA)>20 packs-year, asthma patients with no smoking exposure (NSA) and COPD patients with BEo (COPD)3% or BEo>300 UI/mcl. Periostin concentration in serum was determined by ELISA.

Results: Sixty-five COPDEo, 44 SA, 89 COPD, and 94 NSA were included. Periostin concentrations were 40,9±15,4, 32,4±11,7, 35,1±12,3, and 41,8±18,2 ng/ml respectively (p
Conclusions: Periostin values are increased in asthma and eosinophilic COPD, but they show a poor correlation with BEo and a mild capacity to predict T2 inflammation in a wide spectrum of COAD.

Original language	Spanish
Pages (from-to)	3978
Number of pages	1
Journal	European Respiratory Journal
Volume	50
DOIs	https://doi.org/10.1183/1393003.congress-2017.PA3978
Publication status	Published - 1 Sept 2017

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de Llano, L. P., Piqueras, F. D. B. G-C., Bobolea, I., de las Cuevas, N., LoPez-Campos, J. L., Plaza, V., Lopez-Vina, A., Torrego, A., Moragon, E. M., Izquierdo, J. L., Callejas, J., Soriano, J., Miravitlles, M., & Soler-Catalunya, J. J. (2017). Periostin as a marker of Th2-related inflammation in patients with different types of chronic obstructive airway disease. European Respiratory Journal, 50, 3978. https://doi.org/10.1183/1393003.congress-2017.PA3978

@article{398276f448c24b2f8409f4d8f9a6f818,

title = "Periostin as a marker of Th2-related inflammation in patients with different types of chronic obstructive airway disease",

abstract = "Introduction: Periostin is a putative biomarker of T2 inflammatory response in asthma, with limited data in other chronic obstructive airway diseases (COAD), such as Asthma COPD Overlap (ACO).Objectives: We aimed to investigate the value of periostin among different phenotypes of COAD, its correlation with other T2 biomarkers and its role in predicting a T2 inflammatory pattern.Methods: Cross-sectional study of patients older than 40 years with a post-bronchodilator FEV1/FVC200UI/mcl, asthma with a smoking exposure (SA)>20 packs-year, asthma patients with no smoking exposure (NSA) and COPD patients with BEo (COPD)3% or BEo>300 UI/mcl. Periostin concentration in serum was determined by ELISA.Results: Sixty-five COPDEo, 44 SA, 89 COPD, and 94 NSA were included. Periostin concentrations were 40,9±15,4, 32,4±11,7, 35,1±12,3, and 41,8±18,2 ng/ml respectively (pConclusions: Periostin values are increased in asthma and eosinophilic COPD, but they show a poor correlation with BEo and a mild capacity to predict T2 inflammation in a wide spectrum of COAD.",

author = "{de Llano}, {Luis Perez} and Piqueras, {Fco De Borja Garcia-Cosio} and Irina Bobolea and {de las Cuevas}, Natividad and LoPez-Campos, {Jose Luis} and Vicente Plaza and Antolin Lopez-Vina and Alfons Torrego and Moragon, {Eva Martinez} and Izquierdo, {Jose Luis} and Javier Callejas and Joan Soriano and Marc Miravitlles and Soler-Catalunya, {Juan Jose}",

note = "Copyright {\textcopyright}the authors 2017",

year = "2017",

month = sep,

day = "1",

doi = "10.1183/1393003.congress-2017.PA3978",

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de Llano, LP, Piqueras, FDBG-C, Bobolea, I, de las Cuevas, N, LoPez-Campos, JL, Plaza, V, Lopez-Vina, A, Torrego, A, Moragon, EM, Izquierdo, JL, Callejas, J, Soriano, J, Miravitlles, M & Soler-Catalunya, JJ 2017, 'Periostin as a marker of Th2-related inflammation in patients with different types of chronic obstructive airway disease', European Respiratory Journal, vol. 50, pp. 3978. https://doi.org/10.1183/1393003.congress-2017.PA3978

TY - JOUR

T1 - Periostin as a marker of Th2-related inflammation in patients with different types of chronic obstructive airway disease

AU - de Llano, Luis Perez

AU - Piqueras, Fco De Borja Garcia-Cosio

AU - Bobolea, Irina

AU - de las Cuevas, Natividad

AU - LoPez-Campos, Jose Luis

AU - Plaza, Vicente

AU - Lopez-Vina, Antolin

AU - Torrego, Alfons

AU - Moragon, Eva Martinez

AU - Izquierdo, Jose Luis

AU - Callejas, Javier

AU - Soriano, Joan

AU - Miravitlles, Marc

AU - Soler-Catalunya, Juan Jose

PY - 2017/9/1

Y1 - 2017/9/1

N2 - Introduction: Periostin is a putative biomarker of T2 inflammatory response in asthma, with limited data in other chronic obstructive airway diseases (COAD), such as Asthma COPD Overlap (ACO).Objectives: We aimed to investigate the value of periostin among different phenotypes of COAD, its correlation with other T2 biomarkers and its role in predicting a T2 inflammatory pattern.Methods: Cross-sectional study of patients older than 40 years with a post-bronchodilator FEV1/FVC200UI/mcl, asthma with a smoking exposure (SA)>20 packs-year, asthma patients with no smoking exposure (NSA) and COPD patients with BEo (COPD)3% or BEo>300 UI/mcl. Periostin concentration in serum was determined by ELISA.Results: Sixty-five COPDEo, 44 SA, 89 COPD, and 94 NSA were included. Periostin concentrations were 40,9±15,4, 32,4±11,7, 35,1±12,3, and 41,8±18,2 ng/ml respectively (pConclusions: Periostin values are increased in asthma and eosinophilic COPD, but they show a poor correlation with BEo and a mild capacity to predict T2 inflammation in a wide spectrum of COAD.

AB - Introduction: Periostin is a putative biomarker of T2 inflammatory response in asthma, with limited data in other chronic obstructive airway diseases (COAD), such as Asthma COPD Overlap (ACO).Objectives: We aimed to investigate the value of periostin among different phenotypes of COAD, its correlation with other T2 biomarkers and its role in predicting a T2 inflammatory pattern.Methods: Cross-sectional study of patients older than 40 years with a post-bronchodilator FEV1/FVC200UI/mcl, asthma with a smoking exposure (SA)>20 packs-year, asthma patients with no smoking exposure (NSA) and COPD patients with BEo (COPD)3% or BEo>300 UI/mcl. Periostin concentration in serum was determined by ELISA.Results: Sixty-five COPDEo, 44 SA, 89 COPD, and 94 NSA were included. Periostin concentrations were 40,9±15,4, 32,4±11,7, 35,1±12,3, and 41,8±18,2 ng/ml respectively (pConclusions: Periostin values are increased in asthma and eosinophilic COPD, but they show a poor correlation with BEo and a mild capacity to predict T2 inflammation in a wide spectrum of COAD.

UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=uab_pure&SrcAuth=WosAPI&KeyUT=WOS:000431748903197&DestLinkType=FullRecord&DestApp=WOS

U2 - 10.1183/1393003.congress-2017.PA3978

DO - 10.1183/1393003.congress-2017.PA3978

M3 - Reseña científica

VL - 50

SP - 3978

ER -

Periostin as a marker of Th2-related inflammation in patients with different types of chronic obstructive airway disease

Abstract

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