Periostin as a marker of Th2-related inflammation in patients with different types of chronic obstructive airway disease

Luis Perez de Llano, Fco De Borja Garcia-Cosio Piqueras, Irina Bobolea, Natividad de las Cuevas, Jose Luis LoPez-Campos, Vicente Plaza, Antolin Lopez-Vina, Alfons Torrego, Eva Martinez Moragon, Jose Luis Izquierdo, Javier Callejas, Joan Soriano, Marc Miravitlles, Juan Jose Soler-Catalunya

Research output: Contribution to journalLiterature reviewResearchpeer-review


Introduction: Periostin is a putative biomarker of T2 inflammatory response in asthma, with limited data in other chronic obstructive airway diseases (COAD), such as Asthma COPD Overlap (ACO).

Objectives: We aimed to investigate the value of periostin among different phenotypes of COAD, its correlation with other T2 biomarkers and its role in predicting a T2 inflammatory pattern.

Methods: Cross-sectional study of patients older than 40 years with a post-bronchodilator FEV1/FVC200UI/mcl, asthma with a smoking exposure (SA)>20 packs-year, asthma patients with no smoking exposure (NSA) and COPD patients with BEo (COPD)3% or BEo>300 UI/mcl. Periostin concentration in serum was determined by ELISA.

Results: Sixty-five COPDEo, 44 SA, 89 COPD, and 94 NSA were included. Periostin concentrations were 40,9±15,4, 32,4±11,7, 35,1±12,3, and 41,8±18,2 ng/ml respectively (p
Conclusions: Periostin values are increased in asthma and eosinophilic COPD, but they show a poor correlation with BEo and a mild capacity to predict T2 inflammation in a wide spectrum of COAD.
Original languageSpanish
Pages (from-to)3978
Number of pages1
JournalEuropean Respiratory Journal
Publication statusPublished - 1 Sept 2017

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