TY - JOUR
T1 - Perinatal and childhood factors and risk of breast cancer subtypes in adulthood
AU - Lope, Virginia
AU - García-Esquinas, Esther
AU - Pérez-Gómez, Beatriz
AU - Altzibar, Jone M.
AU - Gracia-Lavedan, Esther
AU - Ederra, María
AU - Molina de la Torre, Antonio José
AU - LLorca, Francisco Javier
AU - Tardón, Adonina
AU - Moreno, Víctor
AU - Bayo, Juan
AU - Salas-Trejo, Dolores
AU - Marcos-Gragera, Rafael
AU - Pumarega, José
AU - Dierssen-Sotos, Trinidad
AU - Lera, Juan Pablo Barrio
AU - de Miguel Medina, M. A.Concepción
AU - Tusquets, Ignasi
AU - Amiano, Pilar
AU - Boldo, Elena
AU - Kogevinas, Manolis
AU - Aragonés, Nuria
AU - Castaño-Vinyals, Gemma
AU - Pollán, Marina
PY - 2016/2/1
Y1 - 2016/2/1
N2 - © 2015 Elsevier Ltd. Background: Accumulated exposure to hormones and growth factors during early life may influence the future risk of breast cancer (BC). This study examines the influence of childhood-related, socio-demographic and anthropometric variables on BC risk, overall and by specific pathologic subtypes. Methods: This is a case-control study where 1539 histologically-confirmed BC cases (23-85 years) and 1621 population controls, frequency matched by age, were recruited in 10 Spanish provinces. Perinatal and childhood-related characteristics were directly surveyed by trained staff. The association with BC risk, globally and according to menopausal status and pathologic subtypes, was evaluated using logistic and multinomial regression models, adjusting for tumor specific risk factors. Results: Birth characteristics were not related with BC risk. However, women with high socioeconomic level at birth presented a decreased BC risk (OR = 0.45; 95% CI = 0.29-0.70), while those whose mothers were aged over 39 years at their birth showed an almost significant excess risk of hormone receptor positive tumors (HR+) (OR = 1.35; 95% CI = 0.99-1.84). Women who were taller than their girl mates before puberty showed increased postmenopausal BC risk (OR = 1.26; 95% CI = 1.03-1.54) and increased HR+ BC risk (OR = 1.26; 95% CI = 1.04-1.52). Regarding prepubertal weight, while those women who were thinner than average showed higher postmenopausal BC risk (OR = 1.46; 95% CI = 1.20-1.78), associated with HR+ tumors (OR = 1.34; 95% CI = 1.12-1.61) and with triple negative tumors (OR = 1.56; 95% CI = 1.03-2.35), those who were heavier than average presented lower premenopausal BC risk (OR = 0.64; 95% CI = 0.46-0.90) and lower risk of epidermal growth factor receptor positive tumors (OR = 0.61; 95% CI = 0.40-0.93). Conclusion: These data reflect the importance of hormones and growth factors in the early stages of life, when the mammary gland is in development and therefore more vulnerable to proliferative stimuli.
AB - © 2015 Elsevier Ltd. Background: Accumulated exposure to hormones and growth factors during early life may influence the future risk of breast cancer (BC). This study examines the influence of childhood-related, socio-demographic and anthropometric variables on BC risk, overall and by specific pathologic subtypes. Methods: This is a case-control study where 1539 histologically-confirmed BC cases (23-85 years) and 1621 population controls, frequency matched by age, were recruited in 10 Spanish provinces. Perinatal and childhood-related characteristics were directly surveyed by trained staff. The association with BC risk, globally and according to menopausal status and pathologic subtypes, was evaluated using logistic and multinomial regression models, adjusting for tumor specific risk factors. Results: Birth characteristics were not related with BC risk. However, women with high socioeconomic level at birth presented a decreased BC risk (OR = 0.45; 95% CI = 0.29-0.70), while those whose mothers were aged over 39 years at their birth showed an almost significant excess risk of hormone receptor positive tumors (HR+) (OR = 1.35; 95% CI = 0.99-1.84). Women who were taller than their girl mates before puberty showed increased postmenopausal BC risk (OR = 1.26; 95% CI = 1.03-1.54) and increased HR+ BC risk (OR = 1.26; 95% CI = 1.04-1.52). Regarding prepubertal weight, while those women who were thinner than average showed higher postmenopausal BC risk (OR = 1.46; 95% CI = 1.20-1.78), associated with HR+ tumors (OR = 1.34; 95% CI = 1.12-1.61) and with triple negative tumors (OR = 1.56; 95% CI = 1.03-2.35), those who were heavier than average presented lower premenopausal BC risk (OR = 0.64; 95% CI = 0.46-0.90) and lower risk of epidermal growth factor receptor positive tumors (OR = 0.61; 95% CI = 0.40-0.93). Conclusion: These data reflect the importance of hormones and growth factors in the early stages of life, when the mammary gland is in development and therefore more vulnerable to proliferative stimuli.
KW - Breast cancer subtypes
KW - Case-control study
KW - Childhood factors
KW - Childhood height
KW - Childhood weight
KW - Early life factors
KW - Hormone receptor
KW - Maternal age
KW - Perinatal factors
KW - Spain
U2 - 10.1016/j.canep.2015.11.004
DO - 10.1016/j.canep.2015.11.004
M3 - Article
VL - 40
SP - 22
EP - 30
JO - Cancer Epidemiology
JF - Cancer Epidemiology
SN - 1877-7821
ER -
