Perinatal alterations of thyroid hormones and behaviour in adult rats

S. Darbra*, F. Balada, A. Garau, P. Gatell, J. Sala, M. A. Marti-Carbonell

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)


Several studies have shown the relevance of the neuroendocrinological system in the development and function of the nervous system. In order to observe the influence of thyroid hormones during development on the behaviour of adult rats we induced dysthyroid states during the perinatal period. Results indicate that some behaviours are more susceptible to the action of thyrpid hormones than others. We observed that the thyroid hormone deficiency causes an increase of activity in animals in spite of a large period of rehabilitation. Thyroxine-treated rats showed an anxiogenic behavioural pattern in the elevated plus-maze, while animals rehabilitated from perinatal deficit of thyroid hormones showed an anxiolitic pattern. These findings suggest that an excess of thyroid hormones has less effect on behaviour than a deficiency of these hormones.

Original languageEnglish
Pages (from-to)159-164
Number of pages6
JournalBehavioural Brain Research
Issue number2
Publication statusPublished - Jun 1995


  • Dysthyhroidism
  • Methimazole
  • Thyroid hormone
  • Thyroxine


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