Pd(0)-based synthetic approaches to 1,1-disubstituted-3,4-dimethylenecyclopentanes as intermediates in the preparation of a,a-disubstituted amino acid derivatives possessing indane and diazaindane skeletons

Anna Löpez, Marcial Moreno-Manas, Roser Pleixats, Anna Roglans

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2 Citations (Scopus)

Abstract

A comparison is established between ethyl nitroacetate and ethyl N(diphenylmelhylene)glycinate as anionic glycine equivalents for the preparation of bicyclic or tricyclic a.adisubstituted amino acids. Palladiummediated approaches to 1.1disubstituted-3,4-di méthylène cyclopentanes are presented (intramolecular reductive coupling of 2.6-dibromol.6dienes and cycloisomerization of 1.6enynes). © Springer-Verlag Ibérica 1997.
Original languageEnglish
Pages (from-to)355-362
JournalAnales de Quimica
Volume93
Issue number6
Publication statusPublished - 1 Dec 1997

Keywords

  • 4dimethylene cyclopentanes ,1,6-
  • Anionic glycine equivalents
  • Enyne cycloisomerization
  • I. I-disubstituted 3
  • Palladium catalysis -
  • Reductive coupling

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