PCSK9 plasma concentration is associated with epicardial adipose tissue volume and metabolic control in patients with type 1 diabetes

Helena Sardà, Cristina Colom, Sonia Benitez, Gemma Carreras, Judit Amigó, Inka Miñambres, David Viladés Medel, Francisco Blanco Vaca, Jose Luis Sanchez-Quesada, Antonio Pérez Pérez

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Patients with type 1 diabetes (T1D) have a greater risk of cardiovascular disease. Proconvertase subtilisin-kexin 9 (PCSK9) is involved in the atherosclerosis process. This study aimed to determine the relationship between PCSK9 levels and epicardial adipose tissue (EAT) volume and cardiometabolic variables in patients with T1D. This was an observational cross-sectional study including 73 patients with T1D. Clinical, biochemical and imaging data were collected. We divided the patients into two groups according to their glycemic control and the EAT index (iEAT) percentile. We performed a correlation analysis between the collected variables and PCSK9 levels; subsequently, we performed a multiple regression analysis with the significant parameters. The mean age was 47.6 ± 8.5 years, 58.9% were men, and the BMI was 26.9 ± 4.6 kg/m 2. A total of 31.5%, 49.3% and 34.2% of patients had hypertension, dyslipidemia and smoking habit, respectively. The PCSK9 concentration was 0.37 ± 0.12 mg/L, which was greater in patients with worse glycemic control (HbA1c > 7.5%), dyslipidemia and high EAT volume (iEAT > 75th percentile). The PCSK9 concentration was positively correlated with age (r = 0.259; p = 0.027), HbA1c (r = 0.300; p = 0.011), insulin dose (r = 0.275; p = 0.020), VLDL-C level (r = 0.331; p = 0.004), TG level (r = 0.328; p = 0.005), and iEAT (r = 0.438; p < 0.001). Multiple regression analysis revealed that 25% of the PCSK9 variability was explained by iEAT and HbA1c (p < 0.05). The PCSK9 concentration is associated with metabolic syndrome parameters, poor glycemic control and increased EAT volume in patients with T1D.
Original languageEnglish
Article number7195
JournalScientific Reports
Volume14
DOIs
Publication statusPublished - 26 Mar 2024

Keywords

  • Biomarkers
  • Cardiometabolic risk factors
  • Cardiometabolic traits
  • Cardiovascular disease risk
  • Epicardial adipose tissue
  • Type 1 diabetes
  • Cross-Sectional Studies
  • Dyslipidemias
  • Humans
  • Middle Aged
  • Diabetes Mellitus, Type 1/metabolism
  • Glycated Hemoglobin
  • Male
  • Subtilisin
  • Proprotein Convertase 9/metabolism
  • Adipose Tissue/metabolism
  • Adult
  • Female
  • Epicardial Adipose Tissue

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