Abstract
Background: Given the clinical impression that patients with type 1 multiple endocrine neoplasia (MEN-1) frequently display abnormal glucose and lipoprotein concentrations, we compared affected subjects followed in our outpatient clinic with their non-affected relatives. Methods: The clinical histories of 35 members (19 affected) from six families with MEN-1 were reviewed. Total cholesterol, triglycerides, insulin, glucose, and insulin resistance (homeostasis model) were compared in affected and non-affected subjects. Results: The affected subjects displayed higher total cholesterol and triglycerides and more insulin resistance. Conclusion: Patients with MEN-1 seem to be more insulin-resistant and to have a higher cardiovascular risk than their non-affected relatives. Three non-exclusive, biologically plausible hypotheses are proposed. © 2005 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.
Original language | English |
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Pages (from-to) | 507-509 |
Journal | European Journal of Internal Medicine |
Volume | 16 |
DOIs | |
Publication status | Published - 1 Nov 2005 |
Keywords
- Dyslipidemia
- Hyperparathyroidism
- Insulin resistance
- MEN-1
- Menin