Patients with MEN-1 are more insulin-resistant than their non-affected relatives

Ana M. Wägner; Jesus M. Martín-Campos; Carmen Mayoral; Alberto De Leiva; Francisco Blanco-Vaca

doi:https://doi.org/10.1016/j.ejim.2005.09.008

Patients with MEN-1 are more insulin-resistant than their non-affected relatives

Ana M. Wägner, Jesus M. Martín-Campos, Carmen Mayoral, Alberto De Leiva, Francisco Blanco-Vaca

Research output: Contribution to journal › Article › Research › peer-review

6 Citations (Scopus)

Abstract

Background: Given the clinical impression that patients with type 1 multiple endocrine neoplasia (MEN-1) frequently display abnormal glucose and lipoprotein concentrations, we compared affected subjects followed in our outpatient clinic with their non-affected relatives. Methods: The clinical histories of 35 members (19 affected) from six families with MEN-1 were reviewed. Total cholesterol, triglycerides, insulin, glucose, and insulin resistance (homeostasis model) were compared in affected and non-affected subjects. Results: The affected subjects displayed higher total cholesterol and triglycerides and more insulin resistance. Conclusion: Patients with MEN-1 seem to be more insulin-resistant and to have a higher cardiovascular risk than their non-affected relatives. Three non-exclusive, biologically plausible hypotheses are proposed. © 2005 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	507-509
Journal	European Journal of Internal Medicine
Volume	16
DOIs	https://doi.org/10.1016/j.ejim.2005.09.008
Publication status	Published - 1 Nov 2005

Keywords

Dyslipidemia
Hyperparathyroidism
Insulin resistance
MEN-1
Menin

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@article{71bb2395d59e40ffb800b2f8422a7277,

title = "Patients with MEN-1 are more insulin-resistant than their non-affected relatives",

abstract = "Background: Given the clinical impression that patients with type 1 multiple endocrine neoplasia (MEN-1) frequently display abnormal glucose and lipoprotein concentrations, we compared affected subjects followed in our outpatient clinic with their non-affected relatives. Methods: The clinical histories of 35 members (19 affected) from six families with MEN-1 were reviewed. Total cholesterol, triglycerides, insulin, glucose, and insulin resistance (homeostasis model) were compared in affected and non-affected subjects. Results: The affected subjects displayed higher total cholesterol and triglycerides and more insulin resistance. Conclusion: Patients with MEN-1 seem to be more insulin-resistant and to have a higher cardiovascular risk than their non-affected relatives. Three non-exclusive, biologically plausible hypotheses are proposed. {\textcopyright} 2005 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.",

keywords = "Dyslipidemia, Hyperparathyroidism, Insulin resistance, MEN-1, Menin",

author = "W{\"a}gner, {Ana M.} and Mart{\'i}n-Campos, {Jesus M.} and Carmen Mayoral and {De Leiva}, Alberto and Francisco Blanco-Vaca",

year = "2005",

month = nov,

day = "1",

doi = "https://doi.org/10.1016/j.ejim.2005.09.008",

language = "English",

volume = "16",

pages = "507--509",

journal = "European Journal of Internal Medicine",

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TY - JOUR

T1 - Patients with MEN-1 are more insulin-resistant than their non-affected relatives

AU - Wägner, Ana M.

AU - Martín-Campos, Jesus M.

AU - Mayoral, Carmen

AU - De Leiva, Alberto

AU - Blanco-Vaca, Francisco

PY - 2005/11/1

Y1 - 2005/11/1

N2 - Background: Given the clinical impression that patients with type 1 multiple endocrine neoplasia (MEN-1) frequently display abnormal glucose and lipoprotein concentrations, we compared affected subjects followed in our outpatient clinic with their non-affected relatives. Methods: The clinical histories of 35 members (19 affected) from six families with MEN-1 were reviewed. Total cholesterol, triglycerides, insulin, glucose, and insulin resistance (homeostasis model) were compared in affected and non-affected subjects. Results: The affected subjects displayed higher total cholesterol and triglycerides and more insulin resistance. Conclusion: Patients with MEN-1 seem to be more insulin-resistant and to have a higher cardiovascular risk than their non-affected relatives. Three non-exclusive, biologically plausible hypotheses are proposed. © 2005 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.

AB - Background: Given the clinical impression that patients with type 1 multiple endocrine neoplasia (MEN-1) frequently display abnormal glucose and lipoprotein concentrations, we compared affected subjects followed in our outpatient clinic with their non-affected relatives. Methods: The clinical histories of 35 members (19 affected) from six families with MEN-1 were reviewed. Total cholesterol, triglycerides, insulin, glucose, and insulin resistance (homeostasis model) were compared in affected and non-affected subjects. Results: The affected subjects displayed higher total cholesterol and triglycerides and more insulin resistance. Conclusion: Patients with MEN-1 seem to be more insulin-resistant and to have a higher cardiovascular risk than their non-affected relatives. Three non-exclusive, biologically plausible hypotheses are proposed. © 2005 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.

KW - Dyslipidemia

KW - Hyperparathyroidism

KW - Insulin resistance

KW - MEN-1

KW - Menin

U2 - https://doi.org/10.1016/j.ejim.2005.09.008

DO - https://doi.org/10.1016/j.ejim.2005.09.008

M3 - Article

VL - 16

SP - 507

EP - 509

JO - European Journal of Internal Medicine

JF - European Journal of Internal Medicine

SN - 0953-6205

ER -